◀ Back to EGFR

EGFR — SHC1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of EGFR-SHC1 → EGFR (directlyIncreases, EGFR/SHC1 Activity) Graus-Porta et al., EMBO J 1997
  Evidence: Finally, ErbB-1 activated by all EGF-related peptides (EGF, HB-EGF, BTC and NDF) couples to SHC, whereas only ErbB-1 activated by its own ligands associates with and phosphorylates Cbl.
• OpenBEL Selventa BEL large corpus: Complex of EGFR-SHC1 → EGFR (directlyIncreases, EGFR/SHC1 Activity) Segatto et al., Oncogene 1993
  Evidence: Shc products are phosphorylated on tyrosine by the activated epidermal growth factor receptor (EGFR) and become physically associated with EGFR via their SH2 domain.
• OpenBEL Selventa BEL large corpus: SHC1 → EGFR (increases, SHC1 Activity)
  Evidence: This is taken from supplemental table 2 from PMID 15951569 Cut-offs were 2.25 for increase and 0.5 for decrease LLID were found by converting from GI assession numbers in DAVID Spreadsheet is saved in the project folder for Cell Signaling Project # bduckworth
• BioCarta role of egf receptor transactivation by gpcrs in cardiac hypertrophy: EGF/EGF R complex (EGF-EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta egf signaling pathway: EGF/EGF-R complex (EGF-EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta trefoil factors initiate mucosal healing: TFFs/ErbB1/ERBB2 complex (EGFR-ERBB2-TFF3_TFF2_TFF1) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling: EGF-R (EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta keratinocyte differentiation: EGF/EGF-R complex (EGF-EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta role of erbb2 in signal transduction and oncology: ERBB ligand/ERBB2/ERBB 1/3/4 complex (ERBB2-ERBB4_ERBB3_EGFR) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• KEGG Focal adhesion: EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• KEGG Glioma: EGFR → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• KEGG Glioma: EGFR → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• KEGG ErbB signaling pathway: EGFR → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• KEGG ErbB signaling pathway: EGFR → SHC1/SHC2/SHC3/SHC4 (protein-protein, activation)
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) → mTOR (MTOR) (modification, activates) Iwasaki et al., Endocrinology 1999
  Evidence: mutant phenotype, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) → EGF/EGFR dimer/SHC complex (EGF-EGFR-SHC1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: physical interaction, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: physical interaction, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer/SHC complex (EGF-EGFR-SHC1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: physical interaction, other species
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC complex (EGFR-EGF-SHC1) → EGFR/EGFR/EGF/EGF complex (EGFR-EGF) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Burke et al., Mol Biol Cell 2001
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC complex (EGFR-EGF-SHC1) → p46 SHC (SHC1) (modification, collaborate) Haugh et al., J Biol Chem 1999, Burke et al., Mol Biol Cell 2001
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → p46 SHC (SHC1) (modification, collaborate) Haugh et al., J Biol Chem 1999, Burke et al., Mol Biol Cell 2001
  Evidence: assay, physical interaction
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer complex (EGF-EGFR) → EGF/EGFR dimer/SHC complex (EGF-EGFR-SHC1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer complex (EGF-EGFR) → SHC (SHC1) (modification, collaborate) Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
• NCI Pathway Database EGFR-dependent Endothelin signaling events: EGF/EGFR dimer/SHC complex (EGF-EGFR-SHC1) → SHC (SHC1) (modification, collaborate) Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
• NCI Pathway Database EGFR-dependent Endothelin signaling events: None → EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: mutant phenotype, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: HRAS/GDP complex (HRAS) → EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1) (modification, collaborate)
  Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
  Evidence: mutant phenotype, other species
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → p52 SHC (SHC1) (modification, collaborate) Haugh et al., J Biol Chem 1999, Burke et al., Mol Biol Cell 2001, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → EGFR/EGFR/EGF/EGF/p52 SHC complex (EGFR-EGF-SHC1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Burke et al., Mol Biol Cell 2001, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: p52 SHC (SHC1) → EGFR/EGFR/EGF/EGF/p52 SHC complex (EGFR-EGF-SHC1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Burke et al., Mol Biol Cell 2001, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: None → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) → None (modification, activates) Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC complex (EGFR-EGF-SHC1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p46 SHC complex (EGFR-EGF-SHC1) → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: GRB2/SOS1 complex (GRB2-SOS1) → EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: None → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) → None (modification, activates) Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Internalization of ErbB1: GRB2/SOS1 complex (GRB2-SOS1) → EGFR/EGFR/EGF/EGF/p52 SHC complex (EGFR-EGF-SHC1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: GRB2/SOS1 complex (GRB2-SOS1) → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF/p52 SHC complex (EGFR-EGF-SHC1) → EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
  Evidence: assay, physical interaction
• Reactome Reaction: EGFR → SHC1 (reaction) Sordella et al., Science 2004, Greulich et al., PLoS Med 2005, Han et al., Cancer Biol Ther 2006, Grandal et al., Carcinogenesis 2007*, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007, Kaushansky et al., Chem Biol 2008, VanderKuur et al., J Biol Chem 1995*, Soler et al., Oncogene 1994, Segatto et al., Oncogene 1993, Cohen et al., J Biol Chem 1996, Pinkas-Kramarski et al., EMBO J 1996, Sakaguchi et al., Mol Endocrinol 1998*
• Reactome Reaction: EGFR → SHC1 (indirect_complex) Sordella et al., Science 2004, Greulich et al., PLoS Med 2005, Han et al., Cancer Biol Ther 2006, Grandal et al., Carcinogenesis 2007*, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007, Kaushansky et al., Chem Biol 2008, VanderKuur et al., J Biol Chem 1995*, Soler et al., Oncogene 1994, Segatto et al., Oncogene 1993, Cohen et al., J Biol Chem 1996, Pinkas-Kramarski et al., EMBO J 1996, Sakaguchi et al., Mol Endocrinol 1998*
• WikiPathways Focal Adhesion: BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1 → SHC1/SHC3 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: SHC1 — EGFR van der Geer et al., Proc Natl Acad Sci U S A 1996*, O'Bryan et al., Proc Natl Acad Sci U S A 1996*, Li et al., J Biol Chem 1996*
• IRef Bind Interaction: SHC1 — EGFR Pelicci et al., Cell 1992*
• IRef Bind Interaction: SHC1 — EGFR O'Bryan et al., Proc Natl Acad Sci U S A 1996*
• IRef Bind Interaction: Complex of 25 proteins Blagoev et al., Nat Biotechnol 2003
• IRef Bind Interaction: Complex of 168 proteins Blagoev et al., Nat Biotechnol 2003
• IRef Bind_translation Interaction: SHC1 — EGFR (affinity chromatography technology) O'Bryan et al., Proc Natl Acad Sci U S A 1996*
• IRef Bind_translation Interaction: SHC1 — EGFR (affinity chromatography technology) van der Geer et al., Proc Natl Acad Sci U S A 1996*
• IRef Bind_translation Interaction: SHC1 — EGFR (affinity chromatography technology) van der Geer et al., Proc Natl Acad Sci U S A 1996*, O'Bryan et al., Proc Natl Acad Sci U S A 1996*
• IRef Bind_translation Interaction: SHC1 — EGFR (competition binding) van der Geer et al., Proc Natl Acad Sci U S A 1996*, Li et al., J Biol Chem 1996*
• IRef Bind_translation Interaction: SHC1 — EGFR (affinity chromatography technology) Pelicci et al., Cell 1992*
• IRef Bind_translation Interaction: SHC1 — EGFR (coimmunoprecipitation) Pelicci et al., Cell 1992*
• IRef Bind_translation Interaction: SHC1 — EGFR (affinity chromatography technology) Borg et al., Mol Cell Biol 1996*
• IRef Bind_translation Interaction: SHC1 — EGFR (affinity chromatography technology) Schulze et al., Molecular systems biology 2005
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Crovello et al., J Biol Chem 1998
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Gotoh et al., Proc Natl Acad Sci U S A 1994*
• IRef Biogrid Interaction: EGFR — SHC1 (direct interaction, pull down) Tong et al., Mol Cell Proteomics 2009
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Tong et al., Mol Cell Proteomics 2009
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Sigismund et al., EMBO J 2013*
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Schulze et al., Molecular systems biology 2005
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Foerster et al., Proteomics 2013
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Graus-Porta et al., EMBO J 1997
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Oksvold et al., Eur J Cell Biol 2001*
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Sakaguchi et al., Mol Endocrinol 1998*
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Burke et al., Mol Biol Cell 2001
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Katayama et al., Jpn J Cancer Res 1999*
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Zhang et al., Biochem Biophys Res Commun 1999*
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Tong et al., J Proteome Res 2008
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Levkowitz et al., Mol Cell 1999
• IRef Biogrid Interaction: EGFR — SHC1 (physical association, affinity chromatography technology) Fukazawa et al., J Biol Chem 1996
• IRef Biogrid Interaction: EGFR — SHC1 (direct interaction, unspecified method) Jones et al., Nature 2006
• IRef Dip Interaction: SHC1 — EGFR (physical association, experimental interaction detection) Kotani et al., Biochem J 1998*
• IRef Hprd Interaction: SHC1 — EGFR (in vitro) Blagoev et al., Nat Biotechnol 2003, Schulze et al., Molecular systems biology 2005, Batzer et al., Mol Cell Biol 1994*, Borg et al., Mol Cell Biol 1996*, Sakaguchi et al., Mol Endocrinol 1998*
• IRef Hprd Interaction: SHC1 — EGFR (in vivo) Blagoev et al., Nat Biotechnol 2003, Schulze et al., Molecular systems biology 2005, Batzer et al., Mol Cell Biol 1994*, Borg et al., Mol Cell Biol 1996*, Sakaguchi et al., Mol Endocrinol 1998*
• IRef Hprd Interaction: Complex of 73 proteins (in vivo) Schulze et al., Molecular systems biology 2005
• IRef Hprd Interaction: Complex of 33 proteins (in vivo) Blagoev et al., Nat Biotechnol 2003
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Schulze et al., Molecular systems biology 2005
• IRef Intact Interaction: Complex of GAB1-SHC1-GRB2-EGFR (association, anti bait coimmunoprecipitation) Jung et al., Oncogene 2011
• IRef Intact Interaction: Complex of 23 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005
• IRef Intact Interaction: SHC1 — EGFR (association, coimmunoprecipitation) Batzer et al., Mol Cell Biol 1994*
• IRef Intact Interaction: SHC1 — EGFR (association, coimmunoprecipitation) Okabayashi et al., J Biol Chem 1994*
• IRef Intact Interaction: SHC1 — EGFR (association, competition binding) Okabayashi et al., J Biol Chem 1994*
• IRef Intact Interaction: SHC1 — EGFR (physical association, coimmunoprecipitation) Fukazawa et al., J Biol Chem 1996
• IRef Intact Interaction: SHC1 — EGFR (association, experimental interaction detection) Sakaguchi et al., Mol Endocrinol 1998*
• IRef Intact Interaction: SHC1 — EGFR (physical association, anti bait coimmunoprecipitation) Sakaguchi et al., Mol Endocrinol 1998*
• IRef Intact Interaction: SHC1 — EGFR (direct interaction, protein array) Jones et al., Nature 2006
• IRef Intact Interaction: SHC1 — EGFR (physical association, pull down) Schulze et al., Molecular systems biology 2005
• IRef Intact Interaction: SHC1 — EGFR (physical association, anti bait coimmunoprecipitation) Zhang et al., Oncogene 2011*
• IRef Intact Interaction: SHC1 — EGFR (physical association, anti bait coimmunoprecipitation) Kodigepalli et al., FEBS Lett 2013*
• IRef Intact Interaction: SHC1 — EGFR (association, coimmunoprecipitation) Batzer et al., Mol Cell Biol 1995*
• IRef Intact Interaction: Complex of EGFR-SHC1-GRB2 (association, anti bait coimmunoprecipitation) Kodigepalli et al., FEBS Lett 2013*
• IRef Intact Interaction: Complex of 228 proteins (association, pull down) Blagoev et al., Nat Biotechnol 2003
• IRef Intact Interaction: Complex of 11 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 14 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 29 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 40 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 11 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 12 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 12 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 32 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 13 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 26 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of UBASH3B-CDC37-EGFR-ERBB3-ERRFI1-SHC1-ERBB2-STAT3 (association, anti bait coimmunoprecipitation) Li et al., Molecular systems biology 2013
• IRef Intact Interaction: Complex of 13 proteins (association, pull down) Wang et al., Cancer Cell 2006
• IRef Intact Interaction: Complex of 70 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005
• IRef Intact Interaction: Complex of PIK3R1-SHC1-ERBB2-ERBB3-EGFR (association, pull down) Wang et al., Cancer Cell 2006
• IRef Intact Interaction: Complex of 38 proteins (association, pull down) Blagoev et al., Nat Biotechnol 2003
• IRef Ophid Interaction: SHC1 — EGFR (aggregation, confirmational text mining) Jones et al., Nature 2006, Fukazawa et al., J Biol Chem 1996
• IRef Ophid Interaction: SHC1 — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Liu et al., J Cell Sci 1999 : Phosphorylation and activation of EGFR were followed by phosphorylation of adaptor protein Shc and activation of MAP kinase
Ricketts et al., Mol Endocrinol 1999 : However, in the PTX-sensitive thrombin pathway, both betagamma function and the epidermal growth factor receptor (EGFR) are necessary for Shc phosphorylation and BrdU incorporation
Vacca et al., Cancer Res 2000 (MAP Kinase Signaling System...) : Specific inhibition of EGF-R kinase activity by tyrphostin AG1478 prevented ET-1 induced transactivation of the EGF-R, as well as Shc phosphorylation and recruitment with Grb2
Cai et al., Am J Physiol Cell Physiol 2008 : AGE induced OS is suppressed by AGER1, an AGE-receptor that counteracts receptor for advanced glycation end products ( RAGE ) and epidermal growth factor receptor (EGFR) mediated Shc/Ras signal activation, resulting in decreased OS
Wang et al., J Cell Physiol 2008 : EGFR tyrosine phosphorylation triggered phosphorylation of its down-stream target Shc and the activation of the c-Jun N-terminal kinase (JNK) pathway
Liu et al., EMBO J 2009 : These results suggest that EGF triggers a transient Grb2/Shc mediated association of EGFR with Tyr phosphorylated Tom1L1 to engage the endocytic machinery for endocytosis of the ligand-receptor complex
Chen et al., Mol Cell Biol 1998 : Down-regulation of EGFR expression through pretreatment of cells with EGF also attenuated ERK activation and Shc tyrosine phosphorylation in response to arsenite treatment
Gresham et al., Int J Cancer 1998 (Prostatic Neoplasms) : To investigate early signaling mechanisms used by the EGFR in prostate tumor cells, we have characterized the involvement of the Shc ( src homology 2/x-collagen related ) adapter protein in EGFR signaling in several human prostate tumor cell lines