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DEPTOR — RPTOR

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): mTORC1 complex (MTOR-MLST8-RPTOR) → DEPTOR (DEPTOR) (modification, collaborate) Takeuchi et al., J Biol Chem 2001, Moumen et al., Development 2007
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): mTORC1 complex (MTOR-MLST8-RPTOR) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, collaborate)
  Takeuchi et al., J Biol Chem 2001, Moumen et al., Development 2007
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): DEPTOR (DEPTOR) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, collaborate)
  Takeuchi et al., J Biol Chem 2001, Moumen et al., Development 2007
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): PRAS40 (AKT1S1) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, collaborate)
  Takeuchi et al., J Biol Chem 2001, Moumen et al., Development 2007
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) → AKT1-2-active (AKT1/AKT2) (modification, collaborate) Takeuchi et al., J Biol Chem 2001, Moumen et al., Development 2007
  Evidence: mutant phenotype
• NCI Pathway Database mTOR signaling pathway: mTOR/GBL/PRAS40/DEPTOR complex (MTOR-MLST8-DEPTOR-AKT1S1) → RAPTOR (RPTOR) (modification, collaborate) Fang et al., Science 2001, Toschi et al., Mol Cell Biol 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database mTOR signaling pathway: mTOR/GBL/PRAS40/DEPTOR complex (MTOR-MLST8-DEPTOR-AKT1S1) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, collaborate)
  Fang et al., Science 2001, Toschi et al., Mol Cell Biol 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database mTOR signaling pathway: RAPTOR (RPTOR) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, collaborate)
  Fang et al., Science 2001, Toschi et al., Mol Cell Biol 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database mTOR signaling pathway: RagA-B/GTP/RagC-D/GDP complex (RRAGA_RRAGB-RRAGC_RRAGD) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, activates)
  Sancak et al., Science 2008, Kim et al., Nat Cell Biol 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: PML (PML) → mTORC1/PRAS40/DEPTOR/PML complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR-PML) (modification, collaborate)
  Bernardi et al., Nature 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: PML (PML) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, collaborate)
  Bernardi et al., Nature 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: mTORC1/PRAS40/DEPTOR/PML complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR-PML) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, collaborate)
  Bernardi et al., Nature 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, collaborate)
  Gwinn et al., Mol Cell 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) → mTORC1/PRAS40/DEPTOR/14-3-3 family complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, collaborate)
  Gwinn et al., Mol Cell 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) → mTORC1/PRAS40/DEPTOR/14-3-3 family complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, collaborate)
  Gwinn et al., Mol Cell 2008
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: mTORC1 complex (MTOR-MLST8-RPTOR) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, collaborate)
  Garami et al., Mol Cell 2003, Inoki et al., Genes Dev 2003, Vander Haar et al., Nat Cell Biol 2007, Sancak et al., Mol Cell 2007, Wang et al., J Biol Chem 2007, Peterson et al., Cell 2009
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: mTORC1 complex (MTOR-MLST8-RPTOR) → DEPTOR (DEPTOR) (modification, collaborate) Garami et al., Mol Cell 2003, Inoki et al., Genes Dev 2003, Vander Haar et al., Nat Cell Biol 2007, Sancak et al., Mol Cell 2007, Wang et al., J Biol Chem 2007, Peterson et al., Cell 2009
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: AKT1 (AKT1) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, activates)
  Garami et al., Mol Cell 2003, Inoki et al., Genes Dev 2003, Vander Haar et al., Nat Cell Biol 2007, Sancak et al., Mol Cell 2007, Wang et al., J Biol Chem 2007, Peterson et al., Cell 2009
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: RHEB/GTP complex (RHEB) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, activates)
  Garami et al., Mol Cell 2003, Inoki et al., Genes Dev 2003, Vander Haar et al., Nat Cell Biol 2007, Sancak et al., Mol Cell 2007, Wang et al., J Biol Chem 2007, Peterson et al., Cell 2009
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) → DEPTOR (DEPTOR) (modification, collaborate) Garami et al., Mol Cell 2003, Inoki et al., Genes Dev 2003, Vander Haar et al., Nat Cell Biol 2007, Sancak et al., Mol Cell 2007, Wang et al., J Biol Chem 2007, Peterson et al., Cell 2009
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database mTOR signaling pathway: mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) → PRAS40 (AKT1S1) (modification, collaborate) Garami et al., Mol Cell 2003, Inoki et al., Genes Dev 2003, Vander Haar et al., Nat Cell Biol 2007, Sancak et al., Mol Cell 2007, Wang et al., J Biol Chem 2007, Peterson et al., Cell 2009
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: DEPTOR — RPTOR (physical association, affinity chromatography technology) Peterson et al., Cell 2009
• IRef Biogrid Interaction: DEPTOR — RPTOR (physical association, affinity chromatography technology) Gwinn et al., PloS one 2010*
• IRef Intact Interaction: Complex of DEPTOR-MTOR-RPTOR-RPTOR-DEPTOR-MTOR (physical association, anti bait coimmunoprecipitation) Peterson et al., Cell 2009
• IRef Intact Interaction: Complex of 17 proteins (physical association, anti bait coimmunoprecipitation) Peterson et al., Cell 2009

Text-mined interactions from Literome

Peterson et al., Cell 2009 (Multiple Myeloma) : Loss of DEPTOR activates S6K1, Akt, and SGK1, promotes cell growth and survival, and activates mTORC1 and mTORC2 kinase activities
Liu et al., J Biol Chem 2010 : Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR ... Taken together, our studies reveal that RSV inhibits leucine stimulated mTORC1 activation by promoting mTOR/DEPTOR interaction and thus uncover a novel mechanism by which RSV negatively regulates mTOR activity
Liu et al., Communicative & integrative biology 2011 : Resveratrol inhibits mTOR signaling by targeting DEPTOR
Zhao et al., Mol Cell 2011 : DEPTOR , an inhibitor of mTORC1 and mTORC2, is degraded via ubiquitin-proteasome pathway by an unknown E3 ubiquitin ligase
Zhao et al., Neoplasia (New York, N.Y.) 2012 (Neoplasms) : Recently, we and others found that DEPTOR , a naturally occurring inhibitor of both mTORC1 and mTORC2, was degraded by SCF ( Skp1-Cullin-F box proteins ) E3 ubiquitin ligase, the founding member of cullin-RING-ligases ( CRLs ), resulting in mTOR activation and cell proliferation