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HMGB1 — TLR2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Endogenous TLR signaling:
TLR1 (TLR1)
→
HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1)
(modification, collaborate)
Park et al., Am J Physiol Cell Physiol 2006, Yu et al., Shock 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1 (HMGB1)
→
HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1)
(modification, collaborate)
Park et al., Am J Physiol Cell Physiol 2006, Yu et al., Shock 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1 (HMGB1)
→
TLR2 (TLR2)
(modification, collaborate)
Park et al., Am J Physiol Cell Physiol 2006, Yu et al., Shock 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1)
→
TLR2 (TLR2)
(modification, collaborate)
Park et al., Am J Physiol Cell Physiol 2006, Yu et al., Shock 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK4 (IRAK4)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK4 (IRAK4)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1)
→
MYD88/TIRAP complex (MYD88-TIRAP)
(modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
MYD88/TIRAP complex (MYD88-TIRAP)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Jiang et al., Mol Immunol 2008
:
As shown in in vitro studies, while polyinosinic-polycytidylic acid [ poly ( I:C ) ] and LPS,
TLR3 and TLR4 ligands, respectively, can
induce HMGB1 release from macrophages, CpG DNA, a TLR 9 ligand, does not
Curtin et al., PLoS Med 2009
(Brain Neoplasms...) :
HMGB1 mediates endogenous
TLR2 activation and brain tumor regression
Li et al., Am J Physiol Regul Integr Comp Physiol 2009
(Acute Lung Injury...) :
The results show that
high-mobility group box 1 (HMGB1) through TLR4 signaling
mediates HS-induced surface expression of
TLR2 in the lung and mouse lung vascular endothelial cells ( MLVECs )
Dai et al., J Biol Chem 2010
(Enterocolitis, Necrotizing) :
In seeking to understand the mechanisms involved,
TLR4 dependent
HMGB1 signaling increased RhoA activation in enterocytes, increased phosphorylation of focal adhesion kinase, and increased phosphorylation of cofilin, resulting in increased stress fibers and focal adhesions
Kohka Takahashi et al., Eur J Pharmacol 2013
:
HMGB1 also
up-regulated RAGE, but not
TLR-2 or TLR-4, expression on monocytes, which was inhibited by antibodies ( Abs ) against ICAM-1, B7.1, B7.2 and CD40
Mohammad et al., Exp Eye Res 2013
(Diabetes Mellitus, Experimental...) :
Diabetes
induced significant upregulation of the expression of
HMGB-1 , receptor for advanced glycation end products ( RAGE ), ERK ( 1/2 ) and nuclear transcription factor Kappa B ( NF-?B ), whereas the expression of
toll-like receptor 2 (TLR2) and occludin was significantly downregulated
Li et al., Inflamm Res 2013
(Liver Failure) :
Furthermore, the hepatic levels of HMGB1,
TLR4 , caspase3 and P65 were also
down-regulated by
HMGB1 blockade