Gene interactions and pathways from curated databases and text-mining

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HMGB1 — TLR2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Jiang et al., Mol Immunol 2008 : As shown in in vitro studies, while polyinosinic-polycytidylic acid [ poly ( I:C ) ] and LPS, TLR3 and TLR4 ligands, respectively, can induce HMGB1 release from macrophages, CpG DNA, a TLR 9 ligand, does not
Curtin et al., PLoS Med 2009 (Brain Neoplasms...) : HMGB1 mediates endogenous TLR2 activation and brain tumor regression
Li et al., Am J Physiol Regul Integr Comp Physiol 2009 (Acute Lung Injury...) : The results show that high-mobility group box 1 (HMGB1) through TLR4 signaling mediates HS-induced surface expression of TLR2 in the lung and mouse lung vascular endothelial cells ( MLVECs )
Dai et al., J Biol Chem 2010 (Enterocolitis, Necrotizing) : In seeking to understand the mechanisms involved, TLR4 dependent HMGB1 signaling increased RhoA activation in enterocytes, increased phosphorylation of focal adhesion kinase, and increased phosphorylation of cofilin, resulting in increased stress fibers and focal adhesions
Kohka Takahashi et al., Eur J Pharmacol 2013 : HMGB1 also up-regulated RAGE, but not TLR-2 or TLR-4, expression on monocytes, which was inhibited by antibodies ( Abs ) against ICAM-1, B7.1, B7.2 and CD40
Mohammad et al., Exp Eye Res 2013 (Diabetes Mellitus, Experimental...) : Diabetes induced significant upregulation of the expression of HMGB-1 , receptor for advanced glycation end products ( RAGE ), ERK ( 1/2 ) and nuclear transcription factor Kappa B ( NF-?B ), whereas the expression of toll-like receptor 2 (TLR2) and occludin was significantly downregulated
Li et al., Inflamm Res 2013 (Liver Failure) : Furthermore, the hepatic levels of HMGB1, TLR4 , caspase3 and P65 were also down-regulated by HMGB1 blockade