Gene interactions and pathways from curated databases and text-mining

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IL3 — RAF1

Text-mined interactions from Literome

Sutor et al., J Biol Chem 1999 : Furthermore, agents that elevated cAMP suppressed IL-3 induced c-Raf activation but did not inhibit MEK activation ... Taken together, these results suggest that IL-3 receptors engage and activate both c-Raf and A-Raf in hemopoietic cells
Carroll et al., J Biol Chem 1990 : Interleukin-3 and granulocyte-macrophage colony stimulating factor mediate rapid phosphorylation and activation of cytosolic c-raf ... Interleukin-3 (IL-3) and granulocyte-macrophage colony stimulating factor induce the rapid phosphorylation of the c-raf protein in the growth factor dependent FDC-P1 and DA-3 murine myeloid cell lines ... IL-3 and granulocyte-macrophage colony stimulating factor induce phosphorylation of c-raf at both serine and tyrosine residues
Kanakura et al., Blood 1991 : Granulocyte-macrophage colony stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor dependent myeloid cell line ... GM-CSF and IL-3 rapidly and transiently increased Raf-1 kinase activity using Histone H1 as a substrate in an immune complex kinase assay in vitro
Terada et al., J Biol Chem 1995 : Induction of the dominant negative Ras ( S17N ) effectively inhibited the IL-3 induced activation of c-Raf-1 and mitogen activated protein kinase ( MAPK )