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CCL2 — IL8

Text-mined interactions from Literome

Murao et al., FEBS Lett 1999 : In human vascular endothelial cells, interleukin-1beta and tumor necrosis factor-alpha induced endogenous monocyte chemoattractant protein-1 protein secretion, mRNA expression and promoter activity
Ishikawa et al., J Am Soc Nephrol 1999 : Bioflavonoid quercetin inhibits interleukin-1 induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB
Akoum et al., J Clin Endocrinol Metab 2000 (Endometriosis) : Estradiol amplifies interleukin-1 induced monocyte chemotactic protein-1 expression by ectopic endometrial cells of women with endometriosis ... In the present study we report that estradiol ( E2 ) enhances endometriotic cell responsiveness to the proinflammatory cytokine interleukin-1beta by up-regulating interleukin-1 induced monocyte chemotactic protein-1 (MCP-1) expression at the level of both protein secretion and messenger ribonucleic acid ( mRNA ) synthesis, whereas progesterone had no significant effects
Gillitzer et al., Zentralbl Chir 2000 : Whereas expression of IL-8 and GRO ( growth related oncogene ) direct early neutrophil recruitment, migration of macrophages is stimulated by MCP-1 ( monocyte chemoattractant protein-1 ) and later, lymphocytes are attracted by IP-10 ( gamma-interferon inducible protein-10 ) and Mig ( monokine induced by interferon-gamma )
Biswas et al., Eur J Immunol 2000 : The inducible expression of the neutrophil chemoattractant IL-8 was enhanced by CD30 co-stimulation, as well as that of the CC chemokines I-309 and MDC, whereas the secretion of the monocyte chemotactic protein-1 was not detected
Aukrust et al., J Am Coll Cardiol 2001 (Angina Pectoris...) : 4 ) Monocyte chemoattractant protein-1 enhanced the generation of O2- in monocytes from unstable angina patients, and the antioxidant glutathione-monoethyl ester suppressed the production of IL-8 and MCP-1 in these cells
Momoi et al., Chest 2001 (Adenocarcinoma...) : In A549 cells, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha induced endogenous MCP-1 protein secretion and messenger RNA expression
Nanki et al., J Immunol 2001 (Arthritis, Rheumatoid) : In this study we show that CCL2/monocyte chemotactic protein-1, CCL5/RANTES, and CXCL12/stromal cell derived factor-1 enhanced IL-6 and IL-8 production by fibroblast-like synoviocytes ( FLS ) from patients with RA, and their corresponding receptors, CCR2, CCR5, and CXCR4, respectively, were expressed by RA FLS
Sebastiani et al., Arch Dermatol Res 2002 (Dermatitis, Contact) : Chemokines are produced in a coordinated and sequential manner, with IL-8 and RANTES induced by TNF-alpha during early stages, and MCP-1 , IP-10, Mig, I-TAC, I-309 and MDC induced by IFN-gamma during later stages
Varney et al., In Vivo 2002 (Melanoma...) : In summary, we demonstrated that MCP-1 and M-CSF, critical for monocyte recruitment, activation and differentiation, differentially regulate IL-8 expression and may play an important role in monocyte/macrophage mediated tumor angiogenesis
Elhofy et al., J Leukoc Biol 2005 (Encephalomyelitis, Autoimmune, Experimental) : Overexpression of CCL2 in the CNS resulted in decreased interleukin-12 receptor expression by antigen-specific T cells
Fritz et al., J Orthop Res 2005 (MAP Kinase Signaling System) : Particulate wear debris induced NF-kappaB activation, the major transcriptional regulator of IL-8 and MCP-1 pro-inflammatory genes and, indeed, both IL-8 and MCP-1 chemokine gene expressions were upregulated in titanium particulate stimulated human osteoblasts
Chizzolini et al., Arthritis Res Ther 2006 (Inflammation...) : Thus, Th1 and Th2 cells preferentially induced production of IFN-gamma inducible protein ( IP ) -10 and IL-8 , respectively, whereas monocyte chemoattractant protein (MCP)-1 was equally induced by both subsets at mRNA and protein levels
Lee et al., Cytokine 2008 : We found that MCP-1 and IL-6 expression due to DpE was related to Src, protein kinase C delta (PKC delta), extracellular-signal regulated kinase ( ERK ) and p38 mitogen activated protein kinase ( MAPK ) and IL-8 expression was involved in Src family tyrosine kinase, PKC delta, ERK
Hafez et al., Infect Immun 2009 : We show that the loss of capsule significantly reduced the level of monocyte chemoattractant protein 1 ( MCP-1 ), RANTES, macrophage inflammatory protein 2alpha ( MIP-2alpha ), MIP-2beta, interleukin-8 , and gamma interferon-inducible protein 10 induction by Nissle 1917 in both Caco-2 cells and MCP-1 induction in ex vivo mouse small intestine
Suzuki et al., Rheumatol Int 2010 (Arthritis) : In HUVEC, IL-6 + sIL-6R induced MCP-1 production, but inhibited IL-8 production
Wu et al., J Gen Virol 2010 (Adenoviridae Infections...) : The results showed that IL-8 and IL-6 were induced 8 h after infection and, by 24 h, levels of IL-8, IL-6, MIP-1alpha/beta and MCP-1 were all increased
Breland et al., Cardiovasc Res 2010 (Carotid Stenosis...) : Our main findings were : ( i ) patients with symptomatic carotid stenosis ( n = 29 ), but not those with asymptomatic plaques ( n = 31 ), had significantly raised plasma levels of MCP-4 compared with healthy controls ( n = 20 ) ; ( ii ) in vitro, releasate from activated platelets markedly increased the expression of MCP-4 and CCR2 in THP-1 monocytes, and enhanced the MCP-4 mediated effect on interleukin-8 secretion in these cells, involving the platelet derived chemokine RANTES ; ( iii ) while MCP-1 had no effect on the release of RANTES and interferon-inducible protein of 10 kDa in tumour necrosis factor alpha-pre activated THP-1 monocytes, MCP-4 profoundly enhanced the release of these pro-atherogenic chemokines ; and ( iv ) the data indicate an inflammatory interaction between RANTES and MCP-4, involving CCR2, and mRNA levels of these mediators were markedly up-regulated within symptomatic atherosclerotic carotid plaque ( n = 81 )
Danaher et al., AIDS 2010 : Lopinavir, the most potent inducer of interleukin (IL)-8 expression, also inhibited dsRNA induced monocyte chemotactic protein 1 expression
Lai et al., Int J Gynecol Cancer 2011 (Genital Neoplasms, Female...) : Similar treatment in HeLa cells caused increases in the mRNA levels of CCL2 , CXCL2, IL-6, and IL-8, and in SKOV3 cells, mRNA levels of CCL2, CCL20, CXCL1, CXCL2, IL-6, and IL-8 increased
Burel et al., Nucleic acid therapeutics 2013 : In mice, the alterations at 70 mg/kg/week included spleen weight increase up to 1.4-fold relative to control, increases in alanine aminotransferase and aspartate aminotransferase up to 1.8-fold over control, interleukin-10 increases up to 3.7-fold, and monocyte chemoattractant protein-1 increase up to 1.9-fold over control
Kim et al., Mol Med Report 2013 : Monocyte chemotactic protein-1 (MCP-1)/CCL2, interleukin (IL)-6 and IL-8 increased following DpE treatment and arazyme significantly blocked the increase of MCP-1 , IL-6 and IL-8 expression in cell types
Goppelt-Struebe et al., FEBS Lett 1995 : Synergistic induction of monocyte chemoattractant protein-1 ( MCP-1 ) by platelet derived growth factor and interleukin-1
Hayashi et al., J Neuroimmunol 1995 : Lipopolysaccharide (LPS), interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha induced MCP-1 secretion by astrocytes, but not microglia
Colotta et al., Am J Pathol 1994 : Induction of MCP-1 transcript by thrombin was not reduced by blocking interleukin-1 and tumor necrosis factor, suggesting that these mediators are not involved in thrombin induced expression of MCP-1
Bodine et al., Endocrinology 1996 : Finally, interleukin-1 beta and tumor necrosis factor-alpha ( 1-1000 pM ) stimulated dose dependent increases in the secretion of interleukin-6 and monocyte chemoattractant protein-1 at 34 C and 40C
Langdon et al., Arthritis Rheum 1997 (Arthritis, Rheumatoid) : In IL-1alpha induced cells, OSM costimulation further enhanced MCP-1 release, but inhibited the release of RANTES and IL-8
Matsukawa et al., Lab Invest 1998 (Arthritis) : The production of monocyte chemoattractant protein-1 ( MCP-1 ) and its regulation by TNFalpha, IL-1, and IL-8 were investigated in two rabbit models of arthritis induced by intra-articular injection of lipopolysaccharide (LPS) or monosodium urate ( MSU ) crystals ... Anti-IL-8 IgG had no effect on the production of MCP-1 in either model