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IL8 — SETD2
Text-mined interactions from Literome
Jelkmann et al., Adv Exp Med Biol 2001
(Anemia) :
HIF-1 DNA binding is also
increased by insulin, and by
interleukin-1 and tumor necrosis factor
Natarajan et al., Microvasc Res 2007
(Inflammation) :
Activation of
HIF-1 via the prolyl hydroxylase inhibitor dimethyloxalylglycine
attenuated hemin induced
IL-8 secretion
Loboda et al., Antioxid Redox Signal 2009
:
HIF-1 induction
attenuates Nrf2 dependent
IL-8 expression in human endothelial cells ... Indeed,
HIF-1 mediated downregulation of both
IL-8 and HO-1 was associated with both lowered Nrf2 expression and induction of Bach1, a repressor of Nrf2 transcriptional activity ... Accordingly, overexpression of Nrf2 reversed the inhibitory
effect of
HIF-1 on
IL-8 and HO-1 expression ... The data indicate that
HIF-1 dependent inhibition of
IL-8 expression is caused by downregulation of Nrf2
Florczyk et al., Free Radic Biol Med 2011
(Anoxia) :
Opposite
effects of
HIF-1a and HIF-2a on the regulation of
IL-8 expression in endothelial cells ... Recently we have shown that hypoxia as well as overexpression of the stable form of
hypoxia-inducible factor-1a (HIF-1a) diminished the expression of
interleukin-8 (IL-8) by inhibition of the Nrf2 transcription factor in HMEC-1 cells ... This study reveals the opposite
roles of
HIF-1a and HIF-2a in the regulation of
IL-8 expression in endothelial cells ... However, despite stabilization of both isoforms in hypoxia the effect of
HIF-1 is predominant, and downregulation of
IL-8 expression in hypoxia is
caused by attenuation of Nrf2 and c-Myc
Fernández-Martínez et al., Biochim Biophys Acta 2012
:
These results confirmed that PGE ( 2 ) mediates the effects of ATRA on HIF-1a expression ; iii ) Prostaglandin uptake transporter inhibitor bromocresol green blocked the increase in
HIF-1a expression
induced by PGE ( 2 ) or by PGE ( 2 ) -increasing cytokine
interleukin-1ß , but not by ATRA
Loboda et al., Vascul Pharmacol 2012
:
Although both isoforms may upregulate the expression of pro-angiogenic vascular endothelial growth factor ( VEGF ),
HIF-1 diminished the expression of
interleukin-8 (IL-8) by inhibition of the Nrf2 transcription factor whereas HIF-2 augmented expression of IL-8 in an Nrf2 independent way but via upregulation of SP-1 activity
He et al., Cancer Chemother Pharmacol 2013
(Carcinoma, Non-Small-Cell Lung...) :
EGCG inhibited HPV-16 oncoprotein induced angiogenesis conferred by NSCLC through the inhibition of HIF-1a protein expression and
HIF-1a dependent expression of VEGF,
IL-8 , and CD31 as well as activation of Akt, suggesting that HIF-1a may be a potential target of EGCG against HPV related NSCLC angiogenesis