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EPHB2 — NRG2
Text-mined interactions from Literome
Pignatelli et al., J Cell Sci 2001
(Breast Neoplasms) :
NRG1 and
NRG2 induce G1 progression, which was associated with stimulation of the phosphatidylinositol-3 kinase (PI 3-K) pathway, whereas survival was dependent on
ERK1/ERK2 activation
EsparÃs-Ogando et al., Mol Cell Biol 2002
(Breast Neoplasms...) :
In MCF7 cells,
NRG activated
Erk5 in a time- and dose dependent fashion
Goldsmit et al., Cell Mol Neurobiol 2001
:
N-acetylcysteine, a ROS scavenger, inhibited
NRG induced activation of Ras and
Erk and PC12-ErbB-4 cell differentiation
Yang et al., Mol Cell Neurosci 2005
:
Moreover,
neuregulin induced
Erk activation and AChR expression were attenuated when ErbB endocytosis was blocked
Di Segni et al., J Mol Neurosci 2006
:
NRG induces prolonged activation of PKB/Akt and
Erk
Lok et al., Neuroscience 2007
(Sciatic Neuropathy) :
We showed that overexpression of Gbeta1 or Gbeta2 in COS7 cells attenuates NRG induced extracellular signal regulated kinase ( ERK ) 1/2 activation, whereas suppression of Gbeta2 expression in C2C12 myotubes enhances
NRG mediated
ERK1/2 activation and c-fos transcription