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IL1B — SP1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Chadjichristos et al., J Biol Chem 2003
:
Moreover,
IL-1 beta increased steady-state levels of
Sp1 and Sp3 mRNAs, whereas it enhanced Sp3 protein expression and inhibited Sp1 protein biosynthesis
Liu et al., J Neurochem 2005
(Alzheimer Disease) :
But in primary cortical neurons, decoy and siRNA experiments indicated that the
IL-1beta induction by S100B was
mediated by
Sp1 without evidence of a role for NFkappaB
Brasse-Lagnel et al., FEBS J 2007
:
The inhibition was exerted at the level of the transcription factors Sp1 and nuclear-kappaB : ( a )
interleukin-1beta inhibited the glutamine stimulated DNA binding of
Sp1 , which might be related to a decrease of its glutamine induced O-glycosylation, and ( b ) glutamine induced per se a decrease in the amount of nuclear p65 protein without affecting the stimulating effect of interleukin-1beta on nuclear factor-kappaB, which might be related to the metabolism of glutamine into glutamate
Saha et al., Am J Physiol Gastrointest Liver Physiol 2008
:
The
role of
Sp1 in
IL-1beta and H. pylori mediated regulation of H, K-ATPase gene transcription ... Gelshift assays showed that
IL-1beta increased
Sp1 but not p50 binding to cognate HKalpha probes and that Sp1 also interacts with an HKalpha NF-kappaB site when bound to its cognate HKalpha cis-response element