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CEBPA — PTGS2
Text-mined interactions from Literome
Yeo et al., J Biol Chem 2003
:
In addition, Cox-2 promoter-luciferase reporters with alterations in predicted cis acting transcriptional regulatory elements revealed that
C/EBP , Ets-1, NF-kappaB, and CREB binding sites are
essential for optimal
Cox-2 expression in response to CpG DNA
Tamura et al., J Mol Endocrinol 2003
(Endometrial Neoplasms) :
Employing electrophoretic mobility shift assays, we demonstrated that increased functional binding of
CCAAT/enhancer binding protein ( C/EBP)alpha , C/EBPbeta and upstream stimulatory factor-2 to the CRE and C/EBPalpha and C/EBPbeta to the NF-IL6 site were, at least in part,
responsible for MECM induced
COX-2 expression in ESC ... Moreover, overexpression of
C/EBPalpha and C/EBPbeta significantly
induced COX-2 promoter activity in ESC ... Collectively, these results suggest that the basal and MECM induced transcription of the
COX-2 gene in ESC is
regulated through a combination of the CRE and the NF-IL6 site by functional interactions of
C/EBPalpha and C/EBPbeta
Joo et al., J Biol Chem 2004
:
Concomitantly,
C/EBP-beta becomes acetylated, and expression of the
COX-2 gene
increases
Wu et al., Arterioscler Thromb Vasc Biol 2005
(Cardiovascular Diseases) :
In this review, the
role of
C/EBP in regulating
COX-2 transcription is highlighted
Jeong et al., Biochem Biophys Res Commun 2007
:
Site-specific mutation analyses confirmed that Rd-mediated transcriptional activation of
COX-2 gene was
regulated by
C/EBP and CREB
Oyesanya et al., FASEB J 2008
(Ovarian Neoplasms) :
The consensus sites for
C/EBP in the Cox-2 promoter were
essential for transcriptional activation of
Cox-2 by LPA
Kundu et al., Cancer Lett 2009
(Skin Neoplasms) :
Taken together, the above findings suggest that oligonol
inhibits TPA induced
COX-2 expression by blocking the activation of NF-kappaB and
C/EBP via modulation of MAP kinases and suppresses chemically induced mouse skin tumorigenesis
Jeong et al., J Immunol 2009
(Arthritis, Rheumatoid) :
Site directed mutagenesis revealed that Pin1 mediated transcriptional activation of
COX-2 was coordinately
regulated by NF-kappaB, CREB, and
C/EBP
Han et al., Food Chem Toxicol 2010
:
Thus, DHCT is an effective agent to attenuate
COX-2 production
mediated by the transcription factors
C/EBP and AP-1, and these results enhance our understanding of the anti-inflammatory and anti-cancer properties by DHCT
Hossain et al., Journal of bioscience and bioengineering 2010
(Mechanotransduction, Cellular) :
Compressive force inhibits adipogenesis through
COX-2 mediated down-regulation of PPARgamma2 and
C/EBPalpha ... In conclusion, compressive force inhibited adipogenesis by suppressing expression of PPARgamma2 and
C/EBPalpha in a
COX-2 dependent manner
Kim et al., J Biol Chem 1998
(Carcinoma, Squamous Cell...) :
We also found that C/EBP isoforms are expressed differentially during mouse skin carcinogenesis, suggesting that overexpression of
COX-2 in tumors may be
caused by a change in
C/EBP expression levels