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LEP — MED7
Text-mined interactions from Literome
Elmquist et al., Physiol Behav 2001
(Body Weight) :
We found that
leptin activates neurons in the retrochiasmatic area ( RCA ) and lateral
arcuate nucleus (Arc) that innervate the sympathetic preganglionic neurons in the thoracic spinal cord and also contain cocaine- and amphetamine regulated transcript ( CART )
Proulx et al., Endocrinology 2002
(Weight Gain) :
In the
arcuate nucleus (ARC) , acute
leptin increased SOCS-3 and POMC mRNA levels, but decreased NPY mRNA levels in the rostral part of ARC
Sanchez et al., J Clin Invest 2004
:
Since this maturation in response to leptin requires prohormone processing, we hypothesized that
leptin might
regulate hypothalamic PC1 and
PC2 expression, ultimately leading to coordinated processing of prohormones into mature peptides
Steinberg et al., Endocrinology 2006
(Obesity) :
Both
leptin and CNTF
reduced AMPK activity and acetyl-coenzyme A carboxylase phosphorylation in the
ARC and PVN of control fed mice
Nillni et al., Endocrinology 2007
(Obesity) :
Because biosynthesis of mature peptides in response to leptin requires prohormone processing, it is hypothesized that
leptin might
regulate hypothalamic PC1/3 and
PC2 expression, ultimately leading to coordinated processing of prohormones into mature peptides
Ambati et al., Biofactors 2007
(Body Weight) :
Leptin and CNTF
increased ARC-ME mRNA levels of signal transducer and activator of transcription 3 ( STAT3 ) by 64.5 and 124.7 % ( p < 0.01 ), suppressor of cytokine signaling 3 ( SOCS3 ) by 258.9 and 1063.9 % ( p < 0.01 ), cocaine and amphetamine regulated transcript ( CART ) by 102.7 and 123.1 % ( p < 0.01 ), and proopiomelanocortin ( POMC2 ) by 374.1 and 264.9 % ( p < 0.01 ), respectively
Kirk et al., PloS one 2009
(Hyperphagia...) :
At postnatal Day 30, before the onset of hyperphagia in these animals, serum
leptin is normal, but leptin induced appetite suppression and phosphorylation of STAT3 in the
arcuate nucleus (ARC) are
attenuated ; the level of AgRP-immunoreactivity in the hypothalamic paraventricular nucleus ( PVH ), which derives from neurones in the ARC and is developmentally dependent on leptin, is also diminished
Qi et al., Endocrinology 2010
:
It is widely accepted that
leptin acts on first-order neurons in the
arcuate nucleus (ARC) with information then relayed to other hypothalamic centers ... We used a model of hypothalamo-pituitary disconnection ( HPD ) to determine whether
leptin action on appetite regulating systems
requires the
ARC
Quennell et al., Endocrinology 2011
(Body Weight...) :
In mice with normalized levels of estradiol,
leptin deficiency markedly
reduced kisspeptin gene expression, particularly in the
arcuate nucleus (ARC) , and kisspeptin immunoreactive cell numbers in the rostral periventricular region of the third ventricle ( RP3V )
Riediger et al., Proc Nutr Soc 2012
(Obesity...) :
PYY and
leptin also reverse or
prevent fasting induced activation of the
ARC
Elias et al., Neuron 1998
(Body Weight) :
We found that
leptin activates neurons in the retrochiasmatic area ( RCA ) and lateral
arcuate nucleus (Arc) that innervate the thoracic spinal cord and also contain cocaine- and amphetamine regulated transcript ( CART )