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IL6 — MOG

Text-mined interactions from Literome

Lobell et al., J Immunol 2003 (Encephalomyelitis, Autoimmune, Experimental) : We failed to detect any effects on ex vivo MOG-peptide induced IFN-gamma, TNF-alpha, IL-6 , IL-4, IL-10, and brain derived neurotropic factor expression in splenocytes or CNS derived lymphocytes
Fu et al., J Neuroimmunol 2006 (Encephalomyelitis, Autoimmune, Experimental) : LLDT-8 reduced the incidence and severity of EAE, which was associated with the inhibition of the MOG 35-55 lymphocyte recall response, anti-MOG 35-55 T cell responses , interleukin (IL)-2 and interferon (IFN)-gamma production
De Sarno et al., J Immunol 2008 (Encephalomyelitis, Autoimmune, Experimental) : In vivo lithium therapy suppressed MOG35-55-reactive effector T cell differentiation, greatly reducing in vitro MOG35-55- stimulated proliferation of mononuclear cells from draining lymph nodes and spleens, and MOG35-55 induced IFN-gamma, IL-6 , and IL-17 production by splenocytes isolated from MOG35-55 immunized mice
Serada et al., Proc Natl Acad Sci U S A 2008 (Encephalomyelitis, Autoimmune, Experimental) : In the present study, we found that IL-6 blockade by treatment with an anti-IL-6 receptor monoclonal antibody ( anti-IL-6R mAb ) inhibited the development of EAE and inhibited the induction of myelin oligodendrocyte glycoprotein ( MOG ) peptide-specific CD4 positive, CD8 positive, and Th17 T cells, in inguinal lymph nodes