Tatebe et al., Biochem Biophys Res Commun 2002
(Colonic Neoplasms) :
We also demonstrated that induction of MRP3 and gamma-GCSh was independent of intracellular COX-2 levels
Kang et al., Mol Cancer Ther 2005
(Carcinoma, Non-Small-Cell Lung...) :
Based on our observation that among four human epithelial lung cell lines both MRP1 and COX-2 protein were highly expressed only in A549 cells, we have investigated whether COX-2 regulates the expression of MRP1 Takaoka et al., Oncol Rep 2008
:
These results suggested that the overexpression of COX-2 increases the intracellular production of MRP1 and MRP2 and causes drug resistance to CDDP