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CTNNB1 — TCF7L1

Pathways - manually collected, often from reviews:

• KEGG Wnt signaling pathway: CTNNB1 → LEF1/TCF7/TCF7L1/TCF7L2 (protein-protein, activation)
• KEGG Adherens junction: LEF1/TCF7/TCF7L1/TCF7L2 → CTNNB1 (protein-protein, binding/association)
• KEGG Melanogenesis: CTNNB1 → LEF1/TCF7/TCF7L1/TCF7L2 (protein-protein, activation)
• KEGG Pathways in cancer: CTNNB1 → LEF1/TCF7/TCF7L1/TCF7L2 (protein-protein, activation)
• KEGG Colorectal cancer: CTNNB1 → LEF1/TCF7/TCF7L1/TCF7L2 (protein-protein, activation)
• KEGG Colorectal cancer: CTNNB1 → LEF1/TCF7/TCF7L1/TCF7L2 (protein-protein, activation)
• KEGG Endometrial cancer: CTNNB1 → LEF1/TCF7/TCF7L1/TCF7L2 (protein-protein, activation)
• KEGG Prostate cancer: CTNNB1 → LEF1/TCF7/TCF7L1/TCF7L2 (protein-protein, activation)
• KEGG Thyroid cancer: CTNNB1 → LEF1/TCF7/TCF7L1/TCF7L2 (protein-protein, activation)
• KEGG Basal cell carcinoma: CTNNB1 → LEF1/TCF7/TCF7L1/TCF7L2 (protein-protein, activation)
• KEGG Arrhythmogenic right ventricular cardiomyopathy (ARVC): CTNNB1 → LEF1/TCF7/TCF7L1/TCF7L2 (protein-protein, activation)
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF3/beta catenin/TERT/BRG1 complex (CTNNB1-TCF7L1) → Axin2 (AXIN2) (transcription, activates) Park et al., Nature 2009
  Evidence: reporter gene, physical interaction, other species
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TERT (TERT) → TCF3/beta catenin/TERT/BRG1 complex (CTNNB1-TCF7L1) (modification, collaborate)
  Barker et al., EMBO J 2001, Park et al., Nature 2009
  Evidence: reporter gene, physical interaction, other species
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TERT (TERT) → TCF3/beta catenin complex (CTNNB1-TCF7L1) (modification, collaborate)
  Barker et al., EMBO J 2001, Park et al., Nature 2009
  Evidence: reporter gene, physical interaction, other species
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF3/beta catenin/TERT/BRG1 complex (CTNNB1-TCF7L1) → BRG1 (SMARCA4) (modification, collaborate) Barker et al., EMBO J 2001, Park et al., Nature 2009
  Evidence: reporter gene, physical interaction, other species
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF3/beta catenin/TERT/BRG1 complex (CTNNB1-TCF7L1) → TCF3/beta catenin complex (CTNNB1-TCF7L1) (modification, collaborate)
  Barker et al., EMBO J 2001, Park et al., Nature 2009
  Evidence: reporter gene, physical interaction, other species
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: BRG1 (SMARCA4) → TCF3/beta catenin complex (CTNNB1-TCF7L1) (modification, collaborate)
  Barker et al., EMBO J 2001, Park et al., Nature 2009
  Evidence: reporter gene, physical interaction, other species
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF3/beta catenin/TERT/BRG1 complex (CTNNB1-TCF7L1) → MYC (MYC) (transcription, activates) Park et al., Nature 2009
  Evidence: reporter gene, physical interaction, other species
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF3/beta catenin/TERT/BRG1 complex (CTNNB1-TCF7L1) → Cyclin D1 (CCND1) (transcription, activates) Park et al., Nature 2009
  Evidence: reporter gene, physical interaction, other species
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: beta catenin (CTNNB1) → TCF3/TLE2 complex (TCF7L1-TLE2) (modification, collaborate)
  Brantjes et al., Nucleic Acids Res 2001, Merrill et al., Genes Dev 2001*, Cole et al., Genes Dev 2008*
  Evidence: assay, physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: beta catenin (CTNNB1) → TCF3/beta catenin complex (CTNNB1-TCF7L1) (modification, collaborate)
  Brantjes et al., Nucleic Acids Res 2001, Merrill et al., Genes Dev 2001*, Cole et al., Genes Dev 2008*
  Evidence: assay, physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TLE2 (TLE2) → TCF3/beta catenin complex (CTNNB1-TCF7L1) (modification, collaborate)
  Brantjes et al., Nucleic Acids Res 2001, Merrill et al., Genes Dev 2001*, Cole et al., Genes Dev 2008*
  Evidence: assay, physical interaction
• NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription: TCF3/TLE2 complex (TCF7L1-TLE2) → TCF3/beta catenin complex (CTNNB1-TCF7L1) (modification, collaborate)
  Brantjes et al., Nucleic Acids Res 2001, Merrill et al., Genes Dev 2001*, Cole et al., Genes Dev 2008*
  Evidence: assay, physical interaction
• Reactome Reaction: TCF7L1 → CTNNB1 (direct_complex)
• WikiPathways Neural Crest Differentiation: CTNNB1 → TCF7L1/TCF4 (mim-binding)
• WikiPathways Wnt Signaling Pathway and Pluripotency: CTNNB1 → Complex of TCF7L2-LEF1-TCF7L1-TCF7 (activation)
  
• WikiPathways Arrhythmogenic Right Ventricular Cardiomyopathy: CTNNB1 → LEF1/TCF7/TCF7L2/TCF7L1 (activation)
• WikiPathways DNA Damage Response (only ATM dependent): TCF7/TCF7L1/TCF7L2/LEF1 → CTNNB1 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TCF7L1 — CTNNB1 (association, x-ray crystallography) Graham et al., Cell 2000
• IRef Hprd Interaction: TCF7L1 — CTNNB1 (in vivo) Brantjes et al., Nucleic Acids Res 2001
• IRef Ophid Interaction: TCF7L1 — CTNNB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: TCF7L1 — CTNNB1 (aggregation, confirmational text mining) Brantjes et al., Nucleic Acids Res 2001

Text-mined interactions from Literome

DasGupta et al., Development 1999 : In mice, TOPGAL expression was directly stimulated by a stabilized form of beta -catenin , but was also dependent upon LEF1/TCF3 in skin
Lee et al., J Cell Biol 2001 : Tcf3 synergizes with CK1epsilon to inhibit beta-catenin degradation, whereas CKI-7, an inhibitor of CK1epsilon, reduces the inhibitory effect of Tcf3