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CDKN1A — TP63

Pathways - manually collected, often from reviews:

• NCI Pathway Database Validated transcriptional targets of TAp63 isoforms: TAp63a (tetramer) complex (TP63) → p21CIP1 (CDKN1A) (transcription, activates) Guo et al., Nat Cell Biol 2009*, Deutsch et al., Cell 2011*, Yang et al., Mol Cell 1998*
  Evidence: reporter gene, physical interaction
• NCI Pathway Database Validated transcriptional targets of TAp63 isoforms: TAp63g (tetramer)/NIR complex (TP63-NOC2L) → p21CIP1 (CDKN1A) (transcription, inhibits) MacPartlin et al., J Biol Chem 2005, Guo et al., Nat Cell Biol 2009*, Heyne et al., Nucleic Acids Res 2010*, Deutsch et al., Cell 2011*
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated transcriptional targets of TAp63 isoforms: TAp63g (tetramer)/p300 complex (TP63-EP300) → p21CIP1 (CDKN1A) (transcription, activates) MacPartlin et al., J Biol Chem 2005, Guo et al., Nat Cell Biol 2009*, Heyne et al., Nucleic Acids Res 2010*, Deutsch et al., Cell 2011*
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated transcriptional targets of TAp63 isoforms: TAp63g (tetramer)/p300 complex (TP63-EP300) → p21CIP1 (CDKN1A) (transcription, activates) MacPartlin et al., J Biol Chem 2005, Kommagani et al., Oncogene 2006*, Guo et al., Nat Cell Biol 2009*, Deutsch et al., Cell 2011*
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated transcriptional targets of TAp63 isoforms: TAp63g (tetramer)/p14ARF complex (TP63-CDKN2A) → p21CIP1 (CDKN1A) (transcription, inhibits) MacPartlin et al., J Biol Chem 2005, Kommagani et al., Oncogene 2006*, Guo et al., Nat Cell Biol 2009*, Deutsch et al., Cell 2011*
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Ishida et al., Jpn J Cancer Res 2000 (Neoplasms) : Ad-p73beta and Ad-p51A induced endogenous p21 gene expression more effectively than Ad-p73alpha and Ad-p51B, respectively
Okada et al., Exp Cell Res 2002 (Cell Transformation, Neoplastic) : Unlike p53 and p51A ( TAp63gamma ), however, p51B ( TAp63alpha ) did not activate p21 ( waf1 ) gene expression, nor did it induce apoptosis or hemoglobin production