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FOXO3 — SKP2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: FOXO3 — SKP2 (physical association, affinity chromatography technology) Wu et al., Oncogene 2013*
• IRef Biogrid Interaction: FOXO3 — SKP2 (direct interaction, enzymatic study) Wang et al., Oncogene 2012*
• IRef Biogrid Interaction: FOXO3 — SKP2 (physical association, affinity chromatography technology) Wang et al., Oncogene 2012*

Text-mined interactions from Literome

Lu et al., Pathol Oncol Res 2009 (Carcinoma, Hepatocellular...) : In vitro studies suggested that the degradation of FOXO3a may dependent on the expression of Skp2 in the proliferated Huh7 cells
Wu et al., Oncogene 2013 (Cell Transformation, Neoplastic) : Foxo3a is found to be a transcriptional repressor of Skp2 gene expression by directly binding to the Skp2 promoter, thereby inhibiting Skp2 protein expression ... Finally, we show that the oncogenic activity of Skp2 is repressed by Foxo3a overexpression