Zhang et al., Bioorg Med Chem Lett 2004
:
It was first found that 5F-DNM remarkably inhibited the secretion of interleukin-4 (IL-4) and had a specific inhibition on the expression of CD4 molecules
Liu et al., Bioorg Med Chem Lett 2012
(Schistosomiasis) :
In this study, we further found that 5F-DNM not only markedly inhibited in vitro IL-4 production from human PBMCs, CD4 ( + ) T cells and mouse splenocytes but also strongly inhibited the production of IL-4 in splenocytes from a mouse model of S. japonicum infection