Gene interactions and pathways from curated databases and text-mining

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HLA-DRB1 — IL4

Text-mined interactions from Literome

Itoh-Lindstrom et al., J Immunol 1999 (IgG Deficiency) : Induction of MHC class II expression by IL-4 or LPS was absent on B cells, and Mac-1+ cells showed no detectable induction of MHC class II by either IL-4 , LPS, or IFN-gamma
Kehlen et al., Adv Exp Med Biol 2000 (Pericardial Effusion) : Contrary to the IL-4 induced expression of APN/CD13 as well as of MHC class II in monocytic cells, we could show that TGF-beta is able to augment the APN/CD13 expression but decreases the MHC class II expression
Ulanova et al., Infect Immun 2001 : Activated Th2 cells release IL-4 , which in turn can induce an increase in the expression of MHC class II molecules on monocytes
Fort et al., J Immunol 2001 (Colitis...) : IL-4 did not cause colitis in Rag2 ( -/- ) mice in the absence of T cells, but did induce an increase in MHC class II expression in the lamina propria of the colon, which was blocked by cotreatment with IL-10
te Velde et al., J Immunol 1992 : IL-4 induces MHC class II Ag expression but reduces Fc gamma RI expression
Tomoda et al., Immunology 1992 (Leukemia, Myeloid) : Among those cytokines, interleukin-1 beta (IL-1 beta) had a positive effect on IFN-gamma dependent induction of MHC class II genes
Galy et al., J Immunol 1991 : MHC class II expression was induced by IFN-gamma but not by IL-1 or IL-4
Burgis et al., Int Arch Allergy Immunol 2007 (Leishmaniasis, Cutaneous) : B cells from STAT6+/- mice were unable to secrete IgE in vitro and in vivo and transcripts accompanying IgE class switching were drastically reduced, whereas IL-4 induced upregulation of MHC class II was unimpaired and CD23 expression levels were only slightly affected
Donnelly et al., J Immunol 1990 : IL-4 enhanced monocyte MHC class II Ag ( HLA-DR ) expression in a manner similar to that of IFN-gamma
Vigne et al., Blood 2011 : In addition, IL-36ß enhanced the expression of CD80, CD86, and MHC class II by BMDCs. IL-36 also induced the production of IFN-?, IL-4 , and IL-17 by CD4 ( + ) T cells and cultured splenocytes
Mond et al., J Immunol 1986 : The data presented in this manuscript extend our previous observations that recombinant interferon-gamma ( reIFN-gamma ) can suppress anti-immunoglobulin ( anti-Ig ) -stimulated B cell proliferation, and demonstrate that reIFN-gamma can also suppress B cell stimulation factor type 1 (BSF-1) stimulated increases in expression of MHC class II molecules ( Ia ) on B cells
Kretsovali et al., Nucleic Acids Res 1995 : In the latter, IL-4 induces transcriptionally MHC class II gene expression
Ito et al., J Antibiot (Tokyo) 1995 : Concanamycin B also abrogates the enhancement of the MHC class II expression by IL-4 on mouse lymphocytes
Whitley et al., Mol Immunol 1993 : Interleukin-4 (IL-4) is a multipotent cytokine which stimulates proliferation of B and T lymphocytes, induces B lymphocyte expression of major histocompatibility complex ( MHC) class II molecules and Fc epsilon R II ( CD23 ) molecules, and promotes immunoglobulin class switching to IgE and IgG1
Hart et al., Immunology 1996 : MHC class II expression by monocytes cultured for 7 days with macrophage colony stimulating factor was regulated by IL-4 and LPS in a manner very similar to that detected for freshly isolated monocytes
Morris et al., J Immunol 1998 : In vivo IL-4 responses to anti-IgD antibody are MHC class II dependent and beta 2-microglobulin independent and develop normally in the absence of IL-4 priming of T cells
Lombard-Platet et al., Developmental immunology 1997 : Both IFN-gamma and IL-4 induce MHC class II expression at the surface of mouse pro-B cells