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HLA-DRB1 — IL4
Text-mined interactions from Literome
Itoh-Lindstrom et al., J Immunol 1999
(IgG Deficiency) :
Induction of MHC class II expression by IL-4 or LPS was absent on B cells, and Mac-1+ cells showed no detectable
induction of
MHC class II by either
IL-4 , LPS, or IFN-gamma
Kehlen et al., Adv Exp Med Biol 2000
(Pericardial Effusion) :
Contrary to the
IL-4 induced expression of APN/CD13 as well as of
MHC class II in monocytic cells, we could show that TGF-beta is able to augment the APN/CD13 expression but decreases the MHC class II expression
Ulanova et al., Infect Immun 2001
:
Activated Th2 cells release
IL-4 , which in turn can
induce an increase in the expression of
MHC class II molecules on monocytes
Fort et al., J Immunol 2001
(Colitis...) :
IL-4 did not cause colitis in Rag2 ( -/- ) mice in the absence of T cells, but did
induce an increase in
MHC class II expression in the lamina propria of the colon, which was blocked by cotreatment with IL-10
te Velde et al., J Immunol 1992
:
IL-4 induces
MHC class II Ag expression but reduces Fc gamma RI expression
Tomoda et al., Immunology 1992
(Leukemia, Myeloid) :
Among those cytokines,
interleukin-1 beta (IL-1 beta)
had a positive effect on IFN-gamma dependent induction of
MHC class II genes
Galy et al., J Immunol 1991
:
MHC class II expression was
induced by IFN-gamma but not by IL-1 or
IL-4
Burgis et al., Int Arch Allergy Immunol 2007
(Leishmaniasis, Cutaneous) :
B cells from STAT6+/- mice were unable to secrete IgE in vitro and in vivo and transcripts accompanying IgE class switching were drastically reduced, whereas
IL-4 induced upregulation of
MHC class II was unimpaired and CD23 expression levels were only slightly affected
Donnelly et al., J Immunol 1990
:
IL-4 enhanced monocyte
MHC class II Ag ( HLA-DR ) expression in a manner similar to that of IFN-gamma
Vigne et al., Blood 2011
:
In addition, IL-36ß enhanced the expression of CD80, CD86, and
MHC class II by BMDCs. IL-36 also
induced the production of IFN-?,
IL-4 , and IL-17 by CD4 ( + ) T cells and cultured splenocytes
Mond et al., J Immunol 1986
:
The data presented in this manuscript extend our previous observations that recombinant interferon-gamma ( reIFN-gamma ) can suppress anti-immunoglobulin ( anti-Ig ) -stimulated B cell proliferation, and demonstrate that reIFN-gamma can also suppress
B cell stimulation factor type 1 (BSF-1) stimulated increases in expression of
MHC class II molecules ( Ia ) on B cells
Kretsovali et al., Nucleic Acids Res 1995
:
In the latter,
IL-4 induces transcriptionally
MHC class II gene expression
Ito et al., J Antibiot (Tokyo) 1995
:
Concanamycin B also abrogates the
enhancement of the
MHC class II expression by
IL-4 on mouse lymphocytes
Whitley et al., Mol Immunol 1993
:
Interleukin-4 (IL-4) is a multipotent cytokine which stimulates proliferation of B and T lymphocytes,
induces B lymphocyte expression of major histocompatibility complex (
MHC) class II molecules and Fc epsilon R II ( CD23 ) molecules, and promotes immunoglobulin class switching to IgE and IgG1
Hart et al., Immunology 1996
:
MHC class II expression by monocytes cultured for 7 days with macrophage colony stimulating factor was
regulated by
IL-4 and LPS in a manner very similar to that detected for freshly isolated monocytes
Morris et al., J Immunol 1998
:
In vivo
IL-4 responses to anti-IgD antibody are
MHC class II dependent and beta 2-microglobulin independent and develop normally in the absence of IL-4 priming of T cells
Lombard-Platet et al., Developmental immunology 1997
:
Both IFN-gamma and
IL-4 induce
MHC class II expression at the surface of mouse pro-B cells