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SREBF1 — SREBF2

Pathways - manually collected, often from reviews:

• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: INSIG1/INSIG2 → Complex of INSIG1-SCAP-INSIG2-SREBF2-SREBF1 (mim-binding)
  
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: Complex of SCAP-SREBF2-SREBF1 → Complex of SAR1A-SCAP-SREBF2-SREBF1-SAR1B (mim-binding)
  
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: Complex of SCAP-SREBF2-SREBF1 → SREBF1 (mim-cleavage) Brown et al., Proc Natl Acad Sci U S A 1999*
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: SREBF1 → SREBF2/SREBF1 (activation)
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: SEC13/SEC31A/SEC31B → Complex of 15 proteins (mim-binding)
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: SREBF2/SREBF1 → SREBF2 (unknown)
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: SREBF1 → SREBF2 (mim-binding)
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: SAR1A/SAR1B → Complex of SAR1A-SCAP-SREBF2-SREBF1-SAR1B (mim-binding)
  
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: SCAP → Complex of SCAP-SREBF2-SREBF1 (mim-binding)
  
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: Complex of SCAP-SREBF2-SREBF1 → Complex of INSIG1-SCAP-INSIG2-SREBF2-SREBF1 (mim-binding)
  
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: SEC23A/SEC23B/SEC24A/SEC24B/SEC24C/SEC24D → Complex of 15 proteins (mim-binding)
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: Complex of SAR1A-SCAP-SREBF2-SREBF1-SAR1B → Complex of 15 proteins (mim-binding)
• WikiPathways Sterol Regulatory Element-Binding Proteins (SREBP) signalling: SREBF2/SREBF1 → Complex of SCAP-SREBF2-SREBF1 (mim-binding)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SREBF2 — SREBF1 (direct interaction, fluorescent resonance energy transfer) Zoumi et al., Mol Cell Biol 2005*

Text-mined interactions from Literome

Field et al., J Biol Chem 2001 : It is postulated that under basal conditions, SREBP-1c regulates intestinal fatty acid synthesis and SREBP-2 regulates cholesterol synthesis
Rishi et al., J Biol Chem 2004 : EMSA assays demonstrate that A-SREBP-1 can inhibit the DNA binding of either B-SREBP-1 or B-SREBP-2 in an equimolar competition but does not inhibit the DNA binding of the three B-HLH-ZIP proteins MAX, USF, or MITF, even at 100 molar eq. Chimeric proteins containing the HLH domain of SREBP-1 and the leucine zipper from either MAX, USF, or MITF indicate that both the HLH and leucine zipper regions of SREBP-1 contribute to its dimerization specificity