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PRKAA2 — WNK1
Text-mined interactions from Literome
Wang et al., Circ Res 2010
:
Analysis of aortic endothelial cells from AMPKalpha2 ( -/- ) mice and human umbilical vein endothelial cells expressing dominant negative AMPK or AMPKalpha2-specific siRNA revealed that loss of
AMPK activity
increased NAD ( P ) H oxidase subunit expression ( gp91(phox), p47(phox), p67(phox), NOX1 and -4 ), NAD ( P ) H oxidase mediated superoxide production, 26S proteasome activity, IkappaBalpha degradation, and nuclear translocation of NF-kappaB ( p50 and
p65 ), whereas AMPK activation by AICAR or overexpression of constitutively active AMPK had the opposite effect
Łabuzek et al., Pharmacol Rep 2010
:
Furthermore, the effects of metformin on the release of IL-1ß, IL-6, IL-10, TGF-ß, NO, and ROS as well as on the expression of arginase I, iNOS, NF-?B
p65 and PGC-1a were not
AMPK dependent , because pretreatment of LPS activated microglia with compound C, a pharmacological inhibitor of AMPK, did not reverse the effect of metformin