Gene interactions and pathways from curated databases and text-mining

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MMP9 — NCAM2

Text-mined interactions from Literome

Shichi et al., J Pharmacol Exp Ther 2011 (Brain Ischemia...) : MMP inhibition or MMP-9 gene KO attenuated the infarction, behavioral abnormalities, and decrease of NCAM ( 180 kDa ) observed after MCAO in mice ... The present findings clearly suggest that MMP-2/MMP-9 mediated NCAM proteolysis is implicated in the exacerbation of ischemic neuronal damage
Fujita-Hamabe et al., Biol Pharm Bull 2012 : We conclude that oxidative stress can induce cleavage of NCAM-180 through up-regulation of MMP-9 during the early phase of oxidative stress
Edvardsen et al., Proc Natl Acad Sci U S A 1993 (Glioma) : We report here that the expression of transmembrane NCAM-B , but not of glycosyl-phosphatidylinositol linked NCAM-C, induces a down-regulation of 92-kDa gelatinase ( matrix metalloproteinase 9 ) and interstitial collagenase ( matrix metalloproteinase 1 ), indicating that cellular expression of the recognition molecule NCAM regulates the metabolism of the surrounding matrix