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IL7R — JAK2
Pathways - manually collected, often from reviews:
-
KEGG Jak-STAT signaling pathway:
CNTFR/CRLF2/CSF2RA/CSF2RB/CSF3R/EPOR/GHR/IFNAR1/IFNAR2/IFNGR1/IFNGR2/IFNLR1/IL10RA/IL10RB/IL11RA/IL12RB1/IL12RB2/IL13RA1/IL13RA2/IL15RA/IL20RA/IL20RB/IL21R/IL22RA1/IL22RA2/IL23R/IL2RA/IL2RB/IL2RG/IL3RA/IL4R/IL5RA/IL6R/IL6ST/IL7R/IL9R/LEPR/LIFR/MPL/OSMR/PRLR
→
JAK1/JAK2/JAK3/TYK2
(protein-protein, phosphorylation)
Text-mined interactions from Literome
Faller et al., Int Immunol 2009
(HIV Infections) :
However, where 0.5 microg ml(-1) of Tat has no effect on CD127 expression and 200 pg ml(-1) of IL-7 decreases CD127 by only 14 %, these two together at these same concentrations induce a 35 % reduction in CD127 expression after 24 h. Inhibition of
Janus kinase ( JAK ) completely
blocks IL-7 's ability to down-regulate
CD127 on the surface of CD8 T cells and also abolishes synergy with Tat
van der Plas et al., Leukemia 1996
(Burkitt Lymphoma...) :
Activation of the chimeric
G-CSF-R/IL-7R alpha with G-CSF resulted in a full proliferative response and
induced the phosphorylation of JAK1 but not
JAK2