Gene interactions and pathways from curated databases and text-mining

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IL7R — JAK2

Pathways - manually collected, often from reviews:

  • KEGG Jak-STAT signaling pathway: CNTFR/CRLF2/CSF2RA/CSF2RB/CSF3R/EPOR/GHR/IFNAR1/IFNAR2/IFNGR1/IFNGR2/IFNLR1/IL10RA/IL10RB/IL11RA/IL12RB1/IL12RB2/IL13RA1/IL13RA2/IL15RA/IL20RA/IL20RB/IL21R/IL22RA1/IL22RA2/IL23R/IL2RA/IL2RB/IL2RG/IL3RA/IL4R/IL5RA/IL6R/IL6ST/IL7R/IL9R/LEPR/LIFR/MPL/OSMR/PRLR → JAK1/JAK2/JAK3/TYK2 (protein-protein, phosphorylation)

Text-mined interactions from Literome

Faller et al., Int Immunol 2009 (HIV Infections) : However, where 0.5 microg ml(-1) of Tat has no effect on CD127 expression and 200 pg ml(-1) of IL-7 decreases CD127 by only 14 %, these two together at these same concentrations induce a 35 % reduction in CD127 expression after 24 h. Inhibition of Janus kinase ( JAK ) completely blocks IL-7 's ability to down-regulate CD127 on the surface of CD8 T cells and also abolishes synergy with Tat
van der Plas et al., Leukemia 1996 (Burkitt Lymphoma...) : Activation of the chimeric G-CSF-R/IL-7R alpha with G-CSF resulted in a full proliferative response and induced the phosphorylation of JAK1 but not JAK2