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MMP14 — RHOA
Text-mined interactions from Literome
Annabi et al., J Neurochem 2005
(Brain Neoplasms...) :
We show that the overexpression of the GTPase
RhoA up-regulated
MT1-MMP expression and triggered CD44 shedding from the U-87 glioma cell surface
Muñoz-Nájar et al., Oncogene 2006
(Breast Neoplasms...) :
Inhibition of the small GTPase
RhoA eliminated the hypoxia induced invasion and
blocked the localization of
MT1-MMP to the plasma membrane
Ando et al., J Atheroscler Thromb 2011
:
In this study, we hypothesized that
MT1-MMP may
mediate RhoA and Rac1 activation and their downstream events in thrombin stimulated endothelial cells ... Silencing of
MT1-MMP attenuated thrombin triggered
RhoA and Rac1 activation, resulting in the attenuation of downstream events including Ca ( 2+ ) signaling, NADPH oxidase activity, ROS generation, and TF and PAI-1 expression ... The present study shows that
MT1-MMP mediates the
RhoA/Ca ( 2+ ) and Rac1/NADPH oxidase dependent signaling pathways in thrombin induced vascular responses
Serratì et al., Arthritis Rheum 2013
(Scleroderma, Systemic) :
Motility increase required Rac1 activation and
RhoA inhibition and was
inhibited by an
MMP inhibitor