Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Ohsawa et al., Fundam Clin Pharmacol 2005 : ET-1 also stimulated activation of ERK1/2 and the activation was inhibited by BQ-123, an ETA inhibitor, and TAK044, an ETA/ETB inhibitor, but not by BQ-788, an ETB inhibitor
Cao et al., BMC neuroscience 2011 (MAP Kinase Signaling System...) : Secondhand smoke exposure induces Raf/ERK/MAPK mediated upregulation of cerebrovascular endothelin ETA receptors
Cadwallader et al., Biochem J 1997 : Et-1, but not LPA, was able to activate JNK1 ; pharmacological analysis revealed that the same EtA receptor mediates DNA synthesis, ERK1 and JNK1 activation
Sansbury et al., Carcinogenesis 1997 (Thymoma) : While PKC eta was expressed at higher levels in sensitive than in resistant cells, overexpression of PKC eta did not restore phorbol ester induced ERK activation to resistant cells