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EPHB2 — HIF1A

Text-mined interactions from Literome

Fukuda et al., Cancer Res 2003 (Colonic Neoplasms) : Pharmacologic inhibition of ERK phosphorylation blocks the induction of VEGF mRNA and HIF-1alpha protein expression in response to PGE ( 2 ) stimulation
Roy et al., Surgery 2003 (Anoxia...) : ( 1 ) Morphine inhibits hypoxia induced VEGF transcription, in part, through an HIF-1alpha mediated mechanism and ( 2 ) morphine inhibition of hypoxia induced HIF-1alpha may be mediated by inhibition of ERK 1,2 MAP kinase activity and PI3 kinase activity
Liu et al., Biochem Biophys Res Commun 2003 (Anoxia...) : In a variety of cell lines, the phosphorylation of HIF-1alpha is dependent on ERK or p38, two members of the mitogen activated protein kinase ( MAPK ) superfamily
Wang et al., J Biol Chem 2004 (Neovascularization, Pathologic) : Ras induction of superoxide activates ERK dependent angiogenic transcription factor HIF-1alpha and VEGF-A expression in shock wave stimulated osteoblasts ... Here, we found that SW elevation of VEGF-A expression in human osteoblasts to be mediated by Ras induced superoxide and ERK dependent HIF-1alpha activation ... In support of the observation that superoxide mediated the SW-induced ERK activation and HIF-1alpha transactivation , we further demonstrated that scavenging of superoxide by superoxide dismutase and inhibition of ERK activity by PD98059 decreased HIF-1alpha activation and VEGF-A levels
Pi et al., Circ Res 2005 : Hypoxia inducible factor 1alpha ( HIF1alpha ), a potent mediator of angiogenesis, is positively regulated by the MAP kinases, ERK1/2
Dimova et al., Thromb Haemost 2005 (MAP Kinase Signaling System...) : Thus, IGF-1 activates human PAI-1 gene expression through activation of the PI3-kinase and ERK1/2 via HIF-1alpha
Zhang et al., Exp Cell Res 2006 (Keloid) : Our results also indicated that the enhancement of hypoxia mediated activation of ERK1/2 and Akt requires direct cell-cell interaction between mast cells and keloid fibroblasts, and activation of both ERK1/2 and Akt is involved in the hypoxia dependent HIF-1alpha protein accumulation and VEGF expression in the co-culture system
Oh et al., Cancer Lett 2008 (Uterine Cervical Neoplasms) : PD98059, ERK inhibitor reduced HIF-1 alpha increased by TB4P
Bove et al., J Biol Chem 2008 (Inflammation) : Collectively, our results demonstrate that inflammatory levels of NO inhibit epithelial cell migration, because of suppression of ERK1/2 signaling, and activation of HIF-1alpha and p53, with potential consequences for epithelial repair and remodeling during airway inflammation
Bartella et al., Cancer Res 2008 (Breast Neoplasms) : Using MDA-MB-231 breast cancer cells, we found that ( a ) insulin stimulated leptin mRNA and protein expression, which was associated with increased activation of the leptin gene promoter ; ( b ) insulin increased nuclear accumulation of transcription factors hypoxia inducible factor (HIF)-1alpha and Sp1 and their loading on the leptin promoter ; ( c ) small interfering RNA ( siRNA ) -mediated knockdown of either HIF-1alpha or Sp1 significantly down-regulated insulin induced leptin mRNA and protein expression ; further inhibition of leptin expression was observed under the combined HIF-1alpha and Sp1 siRNA treatment ; ( d ) inhibition of extracellular signal regulated kinase ( ERK ) 1/2 and phosphatidylinositol-3-OH kinase (PI-3K) pathways significantly, albeit partially, decreased insulin dependent leptin mRNA and protein expression, which coincided with reduced association of HIF-1alpha and/or Sp1 with specific leptin promoter regions ; and ( e ) inhibition of ERK1/2 reduced recruitment of both HIF-1alpha and Sp1 to the leptin promoter, whereas down-regulation of PI-3K influenced only HIF-1alpha binding
Yang et al., Invest Ophthalmol Vis Sci 2009 (Anoxia...) : Role of PI3K/Akt and MEK/ERK in mediating hypoxia induced expression of HIF-1alpha and VEGF in laser induced rat choroidal neovascularization
Mori et al., Mol Cancer Res 2009 (Pancreatic Neoplasms) : In conclusion, overexpression of KLF5 in human pancreatic cancer cells is not mediated by KRAS/Raf/MAPK/Erk signaling, but involves the IL-1beta/IL-1R system, p38, and the transcription factor HIF-1alpha
Sumbayev et al., Eur J Immunol 2009 : ERK and p38 MAPK, but not reactive oxygen species ( ROS ), ASK1 or PI 3-kinase, were critical for IgE mediated accumulation of HIF-1alpha , although the latter crucially affected degranulation
Westra et al., BMC musculoskeletal disorders 2010 (Arthritis...) : HIF-1 alpha protein expression in LPS stimulated THP-1 macrophages could be blocked by ERK- and PI3K-inhibitors, but also by the CaMKII inhibitor KN93 ... Expression of HIF-1 alpha and downstream effects in macrophages are regulated by ERK- , PI3K, but also by CaMKII pathways
Fu et al., BMC cell biology 2010 (Anoxia) : The hypoxia induced HIF-1alpha activation, reactive oxygen species ( ROS ) generation and ERK activation might be involved in this response