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EPHB2 — RELA

Text-mined interactions from Literome

Hoshi et al., J Biol Chem 2000 : These results indicate that TRAP and bFGF induced I-kappaB degradation and NF-kappaB activation through a distinct pathway from TNF-alpha and that ERK1/2 may play an important role in NF-kappaB activation induced by TRAP and bFGF
Carter et al., J Biol Chem 2000 : We have shown that both the ERK and p38 mitogen activated protein ( MAP ) kinases are necessary for cytokine gene transcription and that the p38 MAP kinase is required for NF-kappaB-driven transcription, so we hypothesized that the MEK -- > ERK pathway regulated NF-kappaB-driven transcription as well
Zhang et al., Cell Immunol 2000 : The results in this paper indicate that LPS induced NF-kappa B binding activity was independent of PKC, PKA, ERK , and p38 MAPK, but was regulated by proteasome
Valladares et al., Endocrinology 2000 : However, TNFalpha induced NF-kappaB DNA binding activity is independent of p38MAPK and ERK activation
Pearson et al., J Biol Chem 2001 (Cell Transformation, Neoplastic) : Consistent with results from our focus-formation assays, constitutively active variants of MEK5 and MEK1 synergize to activate NF-kappaB , and MEK5 and ERK5 are required for activation of NF-kappaB by RafBXB
Abraham et al., J Immunol 2001 (Endotoxemia...) : In contrast, alpha-adrenergic blockade before endotoxemia was associated with decreased activation of MEK1/2, ERK2 , and CREB, but increased activation of NF-kappa B
Castrillo et al., J Biol Chem 2001 : Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK
Grewal et al., J Biol Chem 2001 : This transactivation resulted in the initiation of multiple cellular signals ( phosphorylation of the EGFRs and ERK and activation of cAMP-responsive element binding protein ( CREB ), NF-kappaB , and E2F ), as well as subsequent rapid down-regulation of cell-surface EGFRs and internalization and desensitization of the EGFRs without change in the total cellular complement of EGFRs
Nakamura et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Analyzing the effects of several inhibitors or mutant receptors revealed that this NF-kappa B activation is mediated neither by MEK/ERK/MAPK nor by the phosphatidylinositol 3-kinase pathway but by STAT5
Jiang et al., Arterioscler Thromb Vasc Biol 2001 : These data suggest that ERK activity is required for persistent NF-kappaB activation by IL-1beta that is necessary for iNOS gene expression
Dhawan et al., J Biol Chem 2002 (MAP Kinase Signaling System...) : Moreover, the NF-kappa B promoter activity decreased with overexpression of dominant negative ERK expression constructs, and EMSA analyses further support the hypothesis that ERK acts upstream of NF-kappa B and regulates the NF-kappa B DNA binding activity
Cho et al., Nitric Oxide 2002 (MAP Kinase Signaling System) : These results demonstrated that bovine type I collagen induces iNOS in serum stimulated murine macrophages through JunB/AP-1 and NF-kappa B activation and that activation of ERK1/2 plays an essential role in JunB/AP-1 activation
Jijon et al., Am J Physiol Cell Physiol 2002 : Furthermore, AP-1 and NF-kappaB DNA binding was not affected by ERK and p38 inhibition
Kim et al., J Neurochem 2002 : PD98059 did not inhibit NF-kappaB binding, demonstrating that ERK was not responsible for NF-kappaB activation
Bozinovski et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Granulocyte/macrophage-colony stimulating factor ( GM-CSF ) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo
Li et al., Am J Physiol Lung Cell Mol Physiol 2002 (MAP Kinase Signaling System) : Recent studies indicate that maximal IL-8 protein expression requires activation of NF-kappaB as well as activation of the MAP kinases ERK , JNK, and p38
Jiang et al., Arterioscler Thromb Vasc Biol 2002 (MAP Kinase Signaling System) : Treatment of VSMCs with PDGF or EGF alone potently induced ERK phosphorylation and DNA synthesis but did not induce NF-kappaB activation or iNOS expression ... Inhibition of ERK phosphorylation with selective inhibitors ( PD98059 or U0126 ) attenuated interleukin-1beta induced persistent NF-kappaB activation and iNOS expression in either the absence or presence of the growth factors ... These results indicate that interleukin-1beta induced expression of NF-kappaB dependent genes, such as iNOS, is potentiated in the presence of growth factors through a mechanism requiring ERK dependent enhanced NF-kappaB activation , and the results also suggest that NF-kappaB activation is not required for PDGF or EGF to trigger DNA synthesis in VSMCs
Takeuchi et al., J Neurochem 2003 (Neuroblastoma) : These results indicate that D2R induced NF-kappaB activation through ERK may be involved in activation of the NCAM promoter, and additionally that other protein kinases such as CaM KII and p38 MAPK also regulate NCAM expression
Bian et al., Exp Eye Res 2003 (Translocation, Genetic) : These results suggest that activation of DEX-sensitive, CSA-resistant MEK/ERK and p38 pathways, and activation of NF-kappaB , PKC, and PTK are essential for IL-8 and MCP-1 expression by hRPE cells
Walsh et al., Am J Respir Cell Mol Biol 2004 (Neuroblastoma) : Inhibition of ERK1/2 prevented NF-kappaB activation
Kwon et al., Arch Pharm Res 2003 : Sodium salicylate inhibits expression of COX-2 through suppression of ERK and subsequent NF-kappaB activation in rat ventricular cardiomyocytes
Jiang et al., J Biol Chem 2004 : In cultured rat vascular smooth muscle cells, sustained activation of ERK is required for interleukin-1beta to persistently activate NF-kappaB
Bai et al., Biochem Biophys Res Commun 2004 : These data suggest that ERK and ERK dependent NF-kappaB activation is required for oxidative stress induced inhibition of osteoblastic differentiation in rabbit BMSC and calvarial osteoblasts
Kato et al., J Am Soc Nephrol 2004 (Peritonitis) : mRNA expression of MCP-1 was abolished by NF-kappaB inhibition, but were not affected by the inhibition of ERK , JNK, or p38
Chae et al., Immunopharmacol Immunotoxicol 2004 : Salicylate regulates COX-2 expression through ERK and subsequent NF-kappaB activation in osteoblasts ... Salicylate treatment inhibited COX-2 expression induced by TNF-alpha/IFN-gamma and regulated the activation of ERK , IKK and IkappaB degradation and subsequent NF-kappaB activation in MC3T3E1 osteoblasts
Je et al., FEBS Lett 2004 (MAP Kinase Signaling System) : HHE increased the activity of p38 MAPK and extracellular signal regulated kinase ( ERK ), but not c-jun NH ( 2 ) -terminal kinase, indicating that p38 MAPK and ERK are closely involved in HHE induced NF-kappaB transactivation ... These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 MAPK and ERK activation associated with oxidative stress in endothelial cells
Ruiz et al., J Biol Chem 2004 : 15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram negative bacteria induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity
Jang et al., J Biol Chem 2004 : In addition, sustained activation of ERK1/2 ( upstream of NF-kappaB ) was observed in bcl-2 overexpressing cells
Rangaswami et al., J Biol Chem 2004 (MAP Kinase Signaling System...) : Wild type NIK, IKKalpha/beta, and ERK1/2 enhanced and kinase negative NIK ( mut NIK ), dominant negative IKKalpha/beta ( dn IKKalpha/beta ), and dn ERK1/2 suppressed the OPN induced NFkappaB activation, uPA secretion, pro-MMP-9 activation, cell motility, and chemoinvasion
Lee et al., Biochem Biophys Res Commun 2004 : However, in the presence of PD98,059, an inhibitor of ERK , and salicylic acid, an NF-kappaB inhibitor, the EPO induced morphological differentiation of astrocytes and expression of FGAP and EPO receptor were reduced
Afaq et al., Int J Cancer 2005 (Edema...) : We also found that topical application of PFE resulted in inhibition of TPA induced phosphorylation of ERK1/2 , p38 and JNK1/2, as well as activation of NF-kappaB and IKKalpha and phosphorylation and degradation of IkappaBalpha
Qian et al., Immunity 2004 (Hypergammaglobulinemia) : CD40- and BAFF mediated survival is significantly increased in Act1-deficent B cells, with stronger IkappaB phosphorylation, processing of NF-kappaB2 ( p100/p52 ), and activation of JNK, ERK , and p38 pathways, indicating that Act1 negatively regulates CD40- and BAFF mediated signaling events
Wang et al., J Biol Chem 2005 : Overexpression of dominant negative Erk ( DN-Erk ) or pre-exposure to ERK inhibitor PD98059 inhibited NF-kappaB
Harii et al., Mol Endocrinol 2005 (Thyroiditis, Autoimmune...) : In this report, we demonstrate TLR3 mRNA and protein are expressed on Fisher rat thyroid cell line-5 ( FRTL-5 ) thyroid cells and are functional because incubating cells with polyinosine-polycytidylic acid causes 1 ) transcriptional activation of both the nuclear factor kappaB (NF-kappaB)/Elk1 and interferon (IFN) regulatory factor-3/IFN-beta signal paths, 2 ) posttranscriptional activation of NF-kappaB and ERK1/2 , and 3 ) increased IFN-beta mRNA
Petlickovski et al., Blood 2005 (Leukemia, Lymphocytic, Chronic, B-Cell...) : This response was characterized by transient phosphorylation of extracellular signal related kinase ( ERK ) and Akt ( protein kinase B [ PKB ] ), lack of activation of c-JUN NH2-terminal kinase (JNK) and p38 mitogen activated protein kinase ( MAPK ), and variable activation of phospholipase Cgamma2 ( PLCgamma2 ) and nuclear factor-kappaB (NF-kappaB)
Reich et al., J Am Soc Nephrol 2005 : One pathway involves the activation of NFkappaB by albumin, and it has been demonstrated that the activation of NFkappaB induced by albumin is dependent on mitogen activated protein kinase ERK1/ERK2
Guo et al., J Immunol 2005 : To identify a molecular basis for this receptor cross-talk, we examined ERK activation and NF-kappaB induction
Tian et al., Blood 2005 (Lymphoma, B-Cell) : Induction of Bcl10 activity caused rapid activation of nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK), but not activation of extracellular signal regulated kinase ( ERK ) or p38 mitogen activated protein ( MAP ) kinases
Ogunwobi et al., Regul Pept 2006 (Colonic Neoplasms) : Activation of NF-kappaB was independent of ERK and p38 MAP kinase
Lee et al., Infect Immun 2005 : Our data indicate that the increased Ets/Elk and NF-kappaB promoter activities associated with M. smegmatis infected macrophages are responsible, at least in part, for the increased TNF-alpha and NOS2 production observed in these infected cells and that ERK1/2 is required for Ets/Elk activity and full TNF-alpha production
Tao et al., Cell Mol Immunol 2004 : In addition, RV reduced phosphorylation of extracellular signal regulated kinase ( ERK1/2 ) and the activation of nuclear factor NF-kappaB induced by formylpeptide receptor agonists
Maeng et al., Cell Signal 2006 : Consistently, inhibition of ERK significantly increased IkappaB kinase (IKK) activity, IkappaBalpha phosphorylation, and nuclear translocation of NF-kappaB induced by VEGF, whereas overexpression of ERK resulted in the loss of these responses to VEGF
Larsen et al., Diabetologia 2005 : ERK activity is required for NFkappaB mediated transcription of Nos2 in insulin producing INS-1E cells, indicating that ERK regulates Nos2 expression by increasing the transactivating capacity of NFkappaB
Ko et al., FEBS Lett 2005 : Our results suggest that PAF induced MMP-9 expression, in a NF-kappaB dependent manner, is regulated by Ca ( 2+ ), PI3K and ERK signaling pathways
Hennig et al., J Nutr Biochem 2006 (Inflammation) : Furthermore, inhibition of ERK activity by PD98059 and PI3K/Akt activity by LY294002 or wortmannin significantly reduced the LA-induced activation of nuclear factor kappa B (NF-kappaB)
Shan et al., Am J Physiol Lung Cell Mol Physiol 2006 (Asthma...) : Complementary studies further demonstrated that the ASM responses to LPS were associated with activation of the ERK1/2 and p38 MAPK signaling pathways, IKK mediated activation of NF-kappaB , and coupling of phosphorylated ERK1/2 with the p65 subunit of NF-kappaB ... Finally, activation of p38 MAPK with anisomycin prevented both the LPS induced stimulation of ERK1/2 mediated NF-kappaB activity and associated changes in ASM responsiveness
Hayakawa et al., American journal of physiology. Renal physiology 2006 (MAP Kinase Signaling System) : Selective suppression of ERK or p38 MAP kinase significantly attenuated activation of NF-kappaB in mesangial cells triggered by coculture with isolated glomeruli
Chen et al., Arterioscler Thromb Vasc Biol 2006 : The balance between caspase-8 and FLIP favored proliferation in SM22-PAI+-VSMCs. Increased expression of NF-kappaB and activation of extracellular signal regulated kinase ( ERK ) were demonstrated in SM22-PAI+-VSMCs ( fold=NF-kappaB=2.2+/-0.1, fold=phosphorylated-ERK=1.6+/-0.1 )
Kefaloyianni et al., Cell Signal 2006 (MAP Kinase Signaling System) : ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts
Kim et al., Biochem Biophys Res Commun 2006 : However, this activation of NF-kappaB requires the PI3K and PKC signaling pathways, but not ERK or JNK
Borrás et al., FASEB J 2006 : Phosphorylation of extracellular regulated kinase (ERK)1/2 led to an activation of NFkappaB , as indicated by increased p50 subunit expression in nuclear extracts, and increased mRNA levels of the antioxidant enzyme manganese-superoxide dismutase ( MnSOD )
Ni et al., Oral Oncol 2007 (Oral Submucous Fibrosis) : NF-kappaB expression induced by safrole in fibroblasts may be mediated by ERK activation and COX-2 signal transduction pathway
Garaude et al., J Immunol 2006 (Leukemia) : shERK5 decreased nuclear accumulation of the NF-kappaB p65 subunit, and conversely, ectopic activation of ERK5 led to constitutive nuclear localization of p65 and increased its ability to trans activate specific reporter genes
Zhi et al., J Leukoc Biol 2007 (Inflammation) : We also found that H2S stimulated the phosphorylation and activation of ERK1/2 , but not of p38 MAPK and JNK, and pretreatment with PD98059, a selective MEK1 antagonist, could inhibit H2S induced NF-kappaB activation markedly
García-García et al., J Immunol 2007 (MAP Kinase Signaling System) : WT FcgammaRIIA and mutants that associated with lipid rafts efficiently activated NF-kappaB , in an ERK dependent manner
Lee et al., J Vet Sci 2007 : In addition, ERK-specific inhibitor, PD 98,059, reversed BPA induced cell death and restored NF-kappaB activity
Cude et al., J Cell Biol 2007 : Stimulation of ERK5 activated nuclear factor kappaB (NFkappaB) through ribosomal S6 kinase 2 (RSK2) mediated phosphorylation and degradation of IkappaB
Guo et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2007 : The inhibition of ERK can suppress the DNA binding activity of NF-kappaB and the cell proliferation mediated by HCV NS3 protein in a dose dependent manner
Park et al., Int Immunopharmacol 2007 (Inflammation) : Molecular mechanisms that govern attenuation of the levels of mRNAs and proteins of these cytokines and iNOS revealed that the PC extract inhibited LPS stimulated phosphorylation of ERK and activation of NF-kappaB
Bae et al., Mol Immunol 2008 (Inflammation) : Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophages ... Immunofluorescence analysis detected nuclear translocation of the NF-kappaB p50 subunit and this was blocked by ERK inhibitor, indicating that GITRL stimulation induced ERK1/2 phosphorylation and subsequent activation of NF-kappaB
Wei et al., Biochem Pharmacol 2007 (Adenocarcinoma...) : Activation of ERK and p38 MAPK appeared to be mediated primarily by transactivation of EGFR, whereas activation of CREB and NF-kappaB was mediated by PKA, PKC and ERK
Peng et al., Toxicology 2007 (Glioma) : Inhibition of ERK , p38 and JNK block the activation of AP-1 and NF-kappaB , suggesting these MAPKs are involved in ( Ac ) ( 5 ) GP-induced transcription regulation
Patel et al., J Biol Chem 2007 : Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2 dependent NF-kappaB and C/EBPbeta activation ... These results, confirmed in primary human hepatocytes and CASMC, demonstrate for the first time that IL-17 is a potent inducer of CRP expression via p38 MAPK and ERK1/2 dependent NF-kappaB and C/EBPbeta activation and suggest that IL-17 may mediate chronic inflammation, atherosclerosis, and thrombosis
Choi et al., Eur J Pharmacol 2007 : These results suggest that isoeugenol and its analogues inhibit NO production and iNOS expression in LPS stimulated RAW 264.7 cells, and that these effects are mediated, at least in part, by blocking the phosphorylation of ERK1/2 and p38 kinase, degradation of I-kappaBalpha, and activation of NF-kappaB
Chen et al., J Cell Biochem 2008 (Hypertrophy...) : Furthermore, ERK inhibitors ( U0126 and PD98059 ) suppressed LPA stimulated activation of NF-kappaB and p65 phosphorylation whereas wortmannin showed no effect on NF-kappaB activation
Cortez et al., Am J Physiol Heart Circ Physiol 2007 : Our data indicate that IL-17 induces MMP-1 in human cardiac fibroblasts directly via p38 MAPK- and ERK dependent AP-1, NF-kappaB , and C/EBP-beta activation and suggest that IL-17 may play a critical role in myocardial remodeling
Ishizuka et al., J Pharmacol Exp Ther 2008 : Inhibition of NF-kappaB activation and inhibition of ERK1/2 phosphorylation inhibited 20-HETE induced ICAM expression ... It seems that 20-HETE triggers NF-kappaB and MAPK/ERK activation and that both signaling pathways participate in the cellular mechanisms by which 20-HETE activates vascular endothelial cells
Kim et al., Brain Res 2007 : Inhibition of ERK1/2 activity by U-0126 also completely blocked the nuclear translocation of NF-kappaB
Kang et al., Biochem Pharmacol 2008 : SK-126 enhanced ERK1/2 and p38 activation following LPS stimulation, but it did not induce phosphorylation of SAPK/JNK and NF-kappaB
Jung et al., Exp Mol Med 2007 (Inflammation) : The results indicate that celastrol effectively attenuated NO and proinflammatory cytokine production via the inhibition of ERK1/2 phosphorylation and NF-kappaB activation in LPS activated microglia
Saha et al., Am J Physiol Gastrointest Liver Physiol 2008 (Helicobacter Infections...) : We conclude that H. pylori inhibits HKalpha gene expression by ERK1/2 mediated NF-kappaB p50 homodimer binding to the HKalpha promoter
Hickey et al., J Leukoc Biol 2008 : CyaA enhanced LPS induced phosphorylation of p38 MAPK and ERK in DC, and inhibitors of p38 MAPK, MEK, or NF-kappaB suppressed IL-10 production in response to LPS and CyaA
Ben-Othman et al., Mol Immunol 2008 (Leishmaniasis...) : This impairment was not due to MAPK deactivation as inhibition of ERK1/2 and p38MAPK, actually enhances the transcriptional activity of NF-kappaB in response to initial contact of Leishmania with the murine macrophagic cell line Raw264.7
Joo et al., J Biol Chem 2008 (Lung Neoplasms) : Our results indicate that the induction of inflammatory genes by farnesol is mediated by the activation of the NF-kappaB pathway and involves MEK1/2-ERK1/2-MSK1 dependent phosphorylation of p65/RelA ( Ser ( 276 ) )
Sethu et al., J Immunol 2008 (Calcium Signaling...) : In addition, the coupling of TNF-alpha to activation of the phosphorylation of ERK1/2 and the activation of NFkappaB were inhibited by pretreating cells with antisense to PLD1, but not to PLD2 ; thus, demonstrating a specific requirement for PLD1
Peng et al., Surgery 2008 (Pancreatitis) : PKC-zeta induces nuclear translocation of NF-kappaB via ERK1/2 dependent mechanisms
Min et al., Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008 (MAP Kinase Signaling System...) : SNP induced the phosphorylation of p38 MAPK and extracellular regulated kinase (ERK) , degradation and phosphorylation of IkappaB, and activation of NF-kappaB
Ogura et al., Int Immunopharmacol 2008 : In this study, we show that ERK and p38 MAP kinase are involved in the downregulation of cell surface TNF-R1 upon exposure to Ac-CHX and the subsequent inhibition of TNF-alpha induced NF-kappaB activation
Kato et al., Cell Immunol 2008 : In comparison to the control cells, introduction of PICOT to RBL-2H3 cells induced increased degranulation and the activation of NFAT and in the expression of IL-4 and TNF-alpha transcripts by FcepsilonRI crosslinking, whereas no significant change was observed with the elevation of ERK1/2 and p38 MAP kinase phosphorylation and NF-kappaB activation by FcepsilonRI aggregation
Lee et al., Food Chem Toxicol 2008 (Necrosis) : Hydrogen peroxide provoked phosphorylation of extracellular regulated kinase (ERK) and c-Jun NH ( 2 ) -terminal kinase ( JNK ), and activation of nuclear factor-kappaB (NF-kappaB)
Kogut et al., Innate Immun 2008 : Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2 dependent activation of AP-1 and NF-kappaB signaling pathways ... Taken together these data demonstrate that FLG and LPS stimulate the up-regulation of expression of IL-6 and CXCLi2 through an ERK1/2 dependent activation of both NF-kappaB and AP-1
Yao et al., J Neurosci 2009 : Blocking TRPC channels and specific downregulation of TRPC channels 1 and 5 resulted in suppression of CCL2 induced ERK/CREB activation but not Akt/NF-kappaB activation
Hu et al., Am J Physiol Cell Physiol 2009 : PD-98059 blocked IL-1beta induced phosphorylation of IKK2, degradation of IkappaB-alpha, and phosphorylation and nuclear translocation of NF-kappaB subunit p65, whereas SB-203580 had a marginal effect, implying that the effect of ERK1/2 is exerted on the canonical IKK2/IkappaB-alpha/p65 pathway of NF-kappaB activation but that the effect of p38 MAPK may not predominantly involve NF-kappaB signaling
Cheng et al., Cell Mol Neurobiol 2009 : IL-17 stimulates migration of carotid artery vascular smooth muscle cells in an MMP-9 dependent manner via p38 MAPK and ERK1/2 dependent NF-kappaB and AP-1 activation
Park et al., Carcinogenesis 2009 (Breast Neoplasms...) : KPS-A decreased PMA induced transcriptional activation of NF-kappaB and AP-1 and inhibited PMA induced phosphorylation of ERK1/2 and Akt
Qi et al., J Cell Physiol 2009 : JAKs inhibitors suppressed IFN-gamma plus TNF-alpha induced production of CXCL10 in parallel with activation of STAT1 and NF-kappaB, while ERK inhibitor suppressed production of CXCL10 as well as activation of NF-kappaB , but not that of STAT1
Song et al., Atherosclerosis 2009 (Coronary Artery Disease) : SAA time-dependently induced transient and significant upregulation of NF-kappaB1 mRNA ; inhibitor studies indicate that activation of NF-kappaB through the ERK1/2 , p38 and JNK MAPKs and the PI3K pathway was involved
Kim et al., Journal of translational medicine 2009 (Ascites...) : Unlike Paclitaxel, ARRY-520 did not induce NF-kappaB activation, did not enhance cytokine secretion, nor induce ERK phosphorylation in Type I EOC cells
Wu et al., Glia 2010 (Gliosis) : LPS triggered upregulation of CHL1 expression mediated through translocation of nuclear factor kappaB (NF-kappaB) to the nucleus is blocked by a specific NF-kappaB inhibitor and by inhibition of PI3K, PKCdelta, and ERK1/2 activities, implicating NF-kappaB as a downstream target for upregulation of CHL1 expression
Weng et al., J Biomed Sci 2009 (Liver Cirrhosis, Biliary...) : Arm also suppressed TNF-alpha induced collagen collagen deposition, NFkappaB activation and MAPK ( p38, ERK1/2 , and JNK ) phosphorylations
Koh et al., J Pharmacol Exp Ther 2010 (Acute Disease...) : Furthermore, we found that specific ERK1/2 and JNK inhibitors reduce NF-kappaB and AP-1 activity
Park et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2009 : HF6-FC exerts its inhibitory effects by suppression of p38 and NF-kappaB but activation of ERK
Chou et al., Chem Biol Interact 2010 : We also found that EK5 markedly suppressed NF-kappaB signaling as detected by the NF-kappaB reporter gene assay but had no effects on the degradation of IkappaBalpha or translocation of NF-kappaB
Zhao et al., Invest Ophthalmol Vis Sci 2010 (Graves Ophthalmopathy...) : Furthermore, the activation of NF-kappaB was significantly affected by ERK1/2 and JNK inhibitors, but not by p38
Kang et al., Molecules (Basel, Switzerland) 2010 : Furthermore, luteolin suppressed the expression of TNF-alpha, IL-8, IL-6, GM-CSF, and COX-2 through a decrease in the intracellular Ca2+ levels, and also showed a suppression of the ERK 1/2, JNK 1/2, and NF-kappaB activation
Martins et al., PloS one 2010 (Salmonella Infections) : This anti-inflammatory effect was correlated with an inhibitory effect of Sb on ST-induced activation of the MAPKs ERK1/2 , p38 and JNK as well as on activation of NF-kappaB
Boucher et al., Viral Immunol 2010 (HIV Infections...) : In THP-1 cells, p38, ERK , and JNK inhibition increased NF-kappaB and Sp1 binding to the IL-12p40 promoter, while inhibiting AP-1 binding
Leitch et al., Eur J Immunol 2010 : This effect did not appear to be mediated via effects on early markers of neutrophil activation ( e.g. surface marker expression, shape change, aggregation and superoxide anion generation ), by direct inhibition of NF-kappaB activation ( assessed by cytoplasmic IkappaBalpha proteolysis and NF-kappaB p65 subunit translocation ) and ERK activation ( determined by specific ERK phosphorylation ) but due to down-regulation ( at protein and mRNA level ) of the survival protein Mcl-1 but not the pro-apoptotic bcl-2 homologue Bim
Lee et al., Int Immunopharmacol 2010 (Dermatitis) : These findings suggest that hirsutenone may exert a preventive effect against microbial endotoxin lipopolysaccharide induced inflammatory skin diseases through inhibition of ERK pathway mediated NF-kappaB activation
Lu et al., J Neurochem 2010 (Ischemia...) : MEK/ERK inhibition also induced I-kappaB phosphorylation and enhanced nuclear factor (NF)-kappaB/DNA binding activity, leading to expression of cellular inhibitors of apoptosis protein 2 ( c-IAP2 ), a known nuclear factor-kappaB (NF-kappaB) regulated endogenous anti-apoptotic molecule
Zawawi et al., J Periodontal Res 2010 : Blockage of moesin function interrupts the LPS response through an inhibition of MyD88, IRAK and TRAF6, negatively affecting subsequent activation of the MAP kinases ( p38 and ERK ), NF-kappaB activation and translocation to the nucleus
Chen et al., J Biol Chem 2010 (Colorectal Neoplasms) : rHSP90alpha induced the activities of ERK , PI3K/Akt, and NF-kappaB p65, but only NF-kappaB activation was involved in HSP90alpha induced integrin alpha(V) expression
Chen et al., TheScientificWorldJournal 2010 : Blocking phosphorylation of ERK1/2 by MAPK inhibitors U0126 and PD98059, and inhibiting activation of NF-?B by IkappaB ( I?B ) kinase inhibitors wedelolactone or IMD-0354, abolished the DSP effects
Nalla et al., Cell Signal 2011 (Meningeal Neoplasms...) : Downregulation of uPA and uPAR, simultaneously by transfecting the cancer cells with bi-cistronic siRNA expressing plasmid ( pU ) inhibited radiation induced ERK activation, nuclear translocation of Rel-A , NF-?B DNA binding activity, and MCP-1 expression
Ibraim et al., Parasites & vectors 2013 : Nitric oxide and cytokine production, MAPKs ( ERK , p38 and JNK ) and NF-kB activation were evaluated
McGilvray et al., J Biol Chem 1997 : Inhibition of tyrosine kinase activity with genistein ( 10 microg/ml ) as well as selective MAP kinase inhibition with the MEK-1 inhibitor PD98059 abolished the VLA-4 dependent ERK tyrosine phosphorylation, inhibited NF kappaB nuclear binding, and abrogated tissue factor expression induced by both VLA-4 cross linking and adhesion to fibronectin in THP-1 cells and human peripheral blood monocytes
Lee et al., Proc Natl Acad Sci U S A 1998 : We have previously shown that mitogen activated protein kinase/ERK kinase kinase 1 ( MEKK1 ) can induce both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight IkappaB kinase complex in vitro