Singleton et al., Am J Respir Cell Mol Biol 2007
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Morphine, DAMGO, thrombin, and LPS induced RhoA/ROCK mediated threonine phosphorylation of S1P(3) , which was blocked by MNTX, suggesting S1P(3) transactivation
Eskan et al., Eur J Immunol 2008
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Our study also shows that S1P1 and S1P3 expression was induced by LPS in HGEC, and this elevated expression enhanced the influence of S1P in its cooperation with TLR4 to increase cytokine production