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NKD2 — WNT1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zhang et al., Mol Cell Biol 2007
:
Nkd inhibits
Wnt signaling by binding the intracellular protein Dishevelled ( Dsh )
Van Raay et al., Dev Biol 2007
:
Overexpression of Nkd1 or
Nkd2a suppressed canonical
Wnt/beta-catenin signaling at multiple stages of early zebrafish development and also exacerbated the cyclopia and axial mesendoderm convergence and extension ( C & E ) defect in the non-canonical Wnt/PCP mutant silberblick ( slb/wnt11 ) ... Reducing
Nkd function using antisense morpholino oligonucleotides
resulted in increased expression of canonical
Wnt/beta-catenin target genes
Chan et al., Dev Biol 2008
:
Nkd is an intracellular protein that is composed of separable membrane- and nuclear-localization sequences ( NLS ) as well as a conserved EF-hand motif that binds the Wnt receptor associated scaffold protein Dishevelled ( Dsh ), but the mechanism by which
Nkd inhibits
Wnt signaling remains a mystery
Hu et al., Molecular cancer 2010
(Neoplasms) :
Down-regulation of
NKD2 causes
Wnt activation and TGFa misdelivery, suggesting its functions in cell homeostasis and prevention of tumorigenesis
Cao et al., Monoclonal antibodies in immunodiagnosis and immunotherapy 2013
(Colorectal Neoplasms) :
Naked2 (NKD2) is a member of the Naked family and negatively
regulates canonical
Wnt signaling