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MYC — PTMA

Pathways - manually collected, often from reviews:

• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) → PTMA (PTMA) (transcription, activates) Frank et al., EMBO Rep 2003, Eilers et al., EMBO J 1991, Gaubatz et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Shiau et al., J Immunol 2007 (Arthritis, Rheumatoid) : Prothymosin alpha (ProT) is regulated by c-Myc , an oncoprotein overexpressed in synovium of rheumatoid arthritis, and is associated with cell proliferation
Mol et al., Mol Cell Biol 1995 : Taken together, the data do not support the idea that Myc activates transcription of the intact human prothymosin alpha gene or reporter constructs that mimic its structure
Kinoshita et al., Virology 1997 : These results suggest that E6 is able to transactivate the c-myc promoter independently of p53, and that the prothymosin alpha promoter is subsequently transactivated by Myc