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EPHB2 — RB1

Text-mined interactions from Literome

Suyama et al., Int J Oncol 2004 (Adenocarcinoma...) : A specific ERK inhibitor, PD98059, blocked paclitaxel induced ERK activation and pRB phosphorylation at Ser795 in Ma-10 cells ... Furthermore, PD98059 inhibited cell cycle progression during paclitaxel treatment, the accumulation of sub-G1 population, and the cytotoxic effect by paclitaxel in Ma-10 cells, suggesting that ERK activation by paclitaxel, subsequent pRB phosphorylation, and the cell cycle progression during paclitaxel treatment are important determinants of sensitivity to paclitaxel
Huynh et al., Int J Oncol 2004 (Carcinoma, Hepatocellular...) : Our data indicate that activated ERK plays an important role in cyclin D1 and Cdk-2 expression and phosphorylation of pRB at Ser780 and Ser795 in liver cancer cells
Sawant et al., Toxicology 2007 (Carbon Tetrachloride Poisoning...) : In contrast to the non-DB rats, CCl ( 4 ) administration led to lower plasma IL-6, decreased ERK1/2 activation, lower cyclin D1, and cdk 4/6 expression resulting in decreased p-pRB and inhibition of liver cell division in the DB rats
Cheng et al., Food Chem Toxicol 2012 (MAP Kinase Signaling System) : Among the three well known mitogen activated protein kinases ( MAPKs ), Rb1 inhibited RANKL induced JNK and p38 phosphorylation, but not ERK1/2
Hashimoto et al., Evidence-based complementary and alternative medicine : eCAM 2012 : Rb1 increased phosphorylation levels of ERK1/2 or Akt in MPP ( + ) -treated PC12 cells, while it reduced phosphorylated p38 or SAPK/JNK