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APOB — MMP3

Text-mined interactions from Literome

Ardans et al., J Leukoc Biol 2002 : ox-LDL, LDL , and HDL alone had no effect on MMP-1, MMP-9 , or TIMP-1 production
Li et al., Circulation 2003 : Ox-LDL increased the expression of MMP-1 ( collagenase ) and MMP-3 ( stromelysin-1 ) in a concentration- and time dependent manner
Kume et al., Nihon rinsho. Japanese journal of clinical medicine 2004 (Arteriosclerosis) : Lectin-like oxidized LDL receptor-1 ( LOX-1 ) is a cell surface receptor for oxidized LDL, which is abundantly expressed in atherosclerotic plaques and is involved in oxidized LDL induced MMP production and apoptosis
Kakinuma et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : To investigate for the presence of oxidized low-density lipoprotein ( ox-LDL ) and lectin-like oxidized LDL receptor 1 ( LOX-1 ) in cartilage specimens from rheumatoid arthritis ( RA ) joints and to determine whether the interaction of ox-LDL with LOX-1 can induce matrix metalloproteinase 3 (MMP-3) in articular cartilage explant culture ... In contrast to native LDL, ox-LDL induced MMP-3 synthesis by articular chondrocytes in association with the induction of LOX-1, which resulted in enhanced secretion of MMP-3 into the culture medium ... Anti-LOX-1 antibody reversed ox-LDL stimulated MMP-3 synthesis to control levels
May et al., Thromb Haemost 2005 (Arteriosclerosis) : We studied the effect of E-LDL on the activation of plasminogen and matrix metalloproteinases ( MMPs ) in monocytes and vascular smooth muscle cells ( VSMCs ) as well as on MMP activation during cellular interactions ... Together, enzymatical modification of LDL allows a direct activation of MMP expression in monocytes and VSMCs, and indirectly promotes the induction of paracrine, cytokine mediated intercellular activation processes
Ishikawa et al., Arthritis Rheum 2012 (Arthritis, Rheumatoid...) : Human RA fibroblast-like synoviocytes ( FLS ) were assessed for ox-LDL induced expression of LOX-1 and ox-LDL induced production of matrix metalloproteinase 1 (MMP-1) and MMP-3 ... Levels of MMP-1 and MMP-3 were enhanced by stimulation of RA FLS with ox-LDL , and the production of both MMPs was inhibited by blockade of the ox-LDL-LOX-1 interaction with the anti-LOX-1 neutralizing antibody or sLOX-1 ... In the knees of mice, blockade of the ox-LDL-LOX-1 interaction suppressed arthritic changes and reduced the expression of MMP-3 induced by ox-LDL