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IL13 — OLR1
Text-mined interactions from Literome
Bhattacharya et al., Tumour Biol 2009
(Adenoma...) :
Regulation of
15-LOX-1 expression is achieved at transcription level by global histone acetylation and may also be
dependent on GATA-6, IL-4 and
IL-13
Hsi et al., Mol Cancer Ther 2011
(Glioblastoma) :
We hypothesize that in GBM,
IL-13 can
induce 15-LOX-1 , which regulates cell apoptosis via signaling through PPAR? and that expression of IL-13Ra2 prevents apoptosis and contributes to tumor growth ... Knocking down
IL-13Ra2 with short interfering RNA dramatically
induces 15-LOX-1 expression, promotes apoptosis, and reduces GBM tumor growth in vivo