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LEP — NGF

Text-mined interactions from Literome

Hristova et al., Med Hypotheses 2006 (Inflammation...) : The specific pathogenic pathways of MetSyn development include : ( 1 ) increased tissue and plasma levels of proinflammatory cytokines Interleukin-1(IL-1), Interleukin-6 (IL-6 ) and tumor necrosis factor - alpha ( TNF-alpha ) caused by inflammatory and/or emotional distress ; ( 2 ) increased plasma levels of neurotrophin - nerve growth factor (NGF) caused by the high IL-1, IL-6 and TNFalpha levels ; ( 3 ) high plasma levels of NGF which enhance activation of : the autonomous nerve system -- vegetodystonia ( disbalance of neurotransmitters ) ; Neuropeptide Y (NPY) -- enhanced feeding, obesity and increased leptin plasma levels ; hypothalamo-pituitary-adrenal axis -- increased corticotropin releasing hormone (CRH) and cortisol ( hormonal disbalance ) ; immune cells -- increased number and degranulation of mastocytes ( MC ) -- immunological disbalance ; ( 4 ) as a result of 1-3 insulin resistance is exhibited leading to diabetes mellitus
Li et al., Theriogenology 2010 : Furthermore, exogenous NGF had significant effects on the secretion of leptin , cell viability, and sperm apoptosis