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CTNNB1 — SMURF2

Text-mined interactions from Literome

Wu et al., Exp Cell Res 2009 (Osteoarthritis) : Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes : a potential mechanism for Smurf2 induced degeneration of articular cartilage ... It is therefore likely that Smurf2 mediated upregulation of beta-catenin through induction of proteasomal degradation of GSK-beta in chondrocytes may activate articular chondrocyte maturation and associated alteration of gene expression, the early events of OA
Wu et al., Ann N Y Acad Sci 2010 (Disease Models, Animal...) : Overexpression of Smurf2 , an E3 ubiquitin ligase, also induces an OA-like phenotype through upregulation of beta-catenin signaling