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CD8A — IFNG
Text-mined interactions from Literome
El-Sheikh et al., J Autoimmun 1999
(Diabetes Mellitus, Type 1) :
Both CD4 ( + ) and
CD8 ( + ) T cells are
required for
IFN-gamma gene expression in pancreatic islets and autoimmune diabetes development in biobreeding rats ... Depletion of either CD4 ( + ) or
CD8 ( + ) T cells completely
prevented IFN-gamma mRNA upregulation in islets of DP-BB rats above the low level expressed in islets of diabetes-resistant ( DR ) BB rats
Cousens et al., J Exp Med 1999
(Lymphocytic Choriomeningitis) :
Under normal conditions of infections, the
CD8 T cell
IFN-gamma response was dependent on endogenous IFN-alpha/beta effects, but was IL-12 independent
Dobashi et al., Hepatology 1999
:
In addition, liver MNC acquired a potent antitumor cytotoxicity by the SEB injection, and both NK cells and NK1 ( + ) T cells but not
cluster of differentiation (CD)8 ( + ) T cells were responsible for the cytotoxicity as demonstrated by either in vivo or in vitro cell depletion experiments, and the NK-type cells were partly
responsible for the increased serum
IFN-gamma
Berger et al., Virology 2000
(Disease Models, Animal...) :
( 3 ) Production of
interferon-gamma , obligatory for resolution of persistent infection, is
dependent on the interaction of virus-specific CD4 ( + ) and
CD8 ( + ) T cells
Yun et al., Infect Immun 2000
(Coccidiosis) :
Selective depletion of CD4 ( + ), but not
CD8 ( + ), cecal tonsil lymphocytes in SC chickens
resulted in a reduced
IFN-gamma mRNA expression, indicating that CD4 ( + ) cells are the primary source of this cytokine
Tvinnereim et al., Infect Immun 2000
:
IFN-gamma knockout ( KO ) mice were used to address the
requirement for
IFN-gamma in
CD8 ( + ) T-cell priming against ( i ) a model exogenous antigen and ( ii ) secreted and nonsecreted L. monocytogenes antigens
Wu et al., Eur J Immunol 2000
:
The presence of IFN-alpha or
IFN-gamma in cultures
enhanced IL-12Rbeta2 expression of CD4 ( + ) and
CD8 ( + ) T cells
Peng et al., J Immunol 2000
:
Soluble
CD8 selectively
inhibited CD8 T cell proliferation and
IFN-gamma production and could also attenuate peptide-specific CD8 T cell responses in vivo
Grohmann et al., J Immunol 2001
(Diabetes Mellitus, Type 1) :
IFN-gamma enhances the inhibitory activity of
CD8 ( + ) DC on Ag presentation by the other subset, blocking the ability of IL-12 treated CD8 ( - ) DC to overcome suppression
Kumar et al., J Immunol Methods 2001
:
In two monkeys studied in detail, the
IFN-gamma response was focussed on a single 20-mer peptide, QGDGANAGQPQAQGDGANAG, and was
dependent on CD4 ( + ), but not
CD8 ( + ), T cells
Noël et al., Int Immunol 2001
:
The production of both
IFN-gamma and IL-2 following SEB stimulation was greatly
impaired in co-cultures containing CD4 ( + ) T cells, but not
CD8 ( + ) T cells, isolated from unresponsive animals
Giovannetti et al., Clin Exp Immunol 2001
(HIV Infections) :
The number of anti-HIV Gag and Pol cytotoxic T lymphocytes precursors ( CTLp ) decreased during HAART and highly correlated with the
CD8 IFN-gamma response
Grohmann et al., J Immunol 2001
:
By virtue of their respective actions on CD8 ( - ) and CD8 ( + ) DC, IL-12 and
IFN-gamma have functionally opposing effects on peptide presentation by the CD8 ( - ) DC subset, and IFN-gamma activated
CD8 ( + ) DC
mediate tolerogenic effects that prevail over the adjuvant activity of IL-12 on CD8 ( - ) DC
Kafrouni et al., J Immunol 2001
:
Delayed clearance of AdCMV-lacZ from the livers of FasL-defective B6.gld mice, but not perforin-deficient B6.pfp ( -/- ) mice, was noted despite no significant differences in initial hepatic
CD8 ( + ) T cell
IFN-gamma or TNF
responses or in activation of intrahepatic cytotoxic lymphocytes cells capable of killing AdCMV-lacZ infected fibroblast targets
Wang et al., Proc Natl Acad Sci U S A 2001
(Malaria, Falciparum) :
Antigen-specific
IFN-gamma responses were detected by enzyme linked immunospot ( ELISPOT ) assays in all subjects to multiple 9- to 23-aa peptides containing class I and/or class II restricted epitopes, and were
dependent on both
CD8 ( + ) and CD4 ( + ) T cells
Cho et al., J Immunol 2001
:
In this study, we demonstrated that non-APC-specific gene expressions
induced significant
CD8 ( + ) CTL and IFN-gamma producing cells and Ab responses, whereas APC-specific gene expressions led to moderate CTL and
IFN-gamma-producers , but no Ab responses
Tau et al., J Immunol 2001
:
Regulation of
IFN-gamma signaling is
essential for the cytotoxic activity of
CD8 ( + ) T cells
Kostense et al., Blood 2002
(Acquired Immunodeficiency Syndrome...) :
In a longitudinal study including 16 individuals infected with HIV-1, we studied both the number and function of HIV-specific
CD8 ( + ) T cells by comparing HLA-peptide tetramer staining and peptide
induced interferon-gamma (IFN-gamma) production
Kelso et al., Int Immunol 2002
:
When CD44 ( low ) CD62L ( high )
CD8 ( + ) lymph node T cells were activated with IL-2 and immobilized antibodies to CD3, CD8 and CD11a, expression of perforin, granzyme B and
IFN-gamma mRNAs was
induced by day 2, and increased in parallel with perforin dependent cytolytic activity
Dunn et al., J Infect Dis 2002
:
To study the dynamics of cytomegalovirus ( CMV ) immunity in healthy immunocompetent hosts,
interferon-gamma producing CD4 and
CD8 T cell
responses in the presence or absence of CMV antigens were measured from 15 CMV-seropositive donors and 13 CMV-seronegative donors
Fadel et al., J Immunol 2002
(Retroviridae Infections...) :
Despite the induction of significant anti-viral
CD8+ mediated cytotoxic T lymphocyte and
IFN-gamma responses, initial neonatal priming led to a lower frequency of virus-specific T cells compared with adult priming
Pien et al., J Immunol 2002
(Lymphocytic Choriomeningitis) :
The kinetics of
CD8 T cell
IFN-gamma responses as they occur in situ are defined here during lymphocytic choriomeningitis virus ( LCMV ) infections, and a unique mechanism for the innate cytokines IFN-alphabeta and IL-18 in promoting these responses is defined ... Production of
IFN-gamma was MHC class
I/CD8 dependent , but did not require IL-12, NK cells, TCR-gammadelta T cells, MHC class II, or CD4 T cells
Wang et al., Int J Cancer 2003
(Carcinoma...) :
Depletion of
CD8 ( + ) T cells
suppressed the production of
interferon-gamma
Segel et al., Am J Physiol Lung Cell Mol Physiol 2003
(Pulmonary Fibrosis) :
CD4+,
CD8+ , and natural killer cells each
contributed significantly to
IFN-gamma production
Liu et al., J Immunol 2003
:
IL-10 mediates suppression of the
CD8 T cell
IFN-gamma response to a novel viral epitope in a primed host
Raez et al., Cancer Gene Ther 2003
(Carcinoma, Non-Small-Cell Lung...) :
Induction of
CD8 T-cell-Ifn-gamma response and positive clinical outcome after immunization with gene modified allogeneic tumor cells in advanced non-small-cell lung carcinoma ... The study demonstrates that
CD8 Ifn-gamma responses against nonimmunogenic or immunosuppressive tumors can be evoked by cellular vaccines even at advanced stages of disease
Ott et al., J Immunol Methods 2004
(Diabetes Mellitus, Type 1...) :
CD4 and
CD8 IFN-gamma responses to viral ( hepatitis C ) and autoimmune antigens ( islet cell ) were tested in 10 hepatitis C and 8 type 1 diabetic as well as healthy control subjects
Hallez et al., Cancer Immunol Immunother 2004
(Cervical Intraepithelial Neoplasia...) :
Five vaccinated patients ( 71 % ) showed significantly increased
IFN-gamma CD8+ cell
responses upon PD-E7 stimulation
Herath et al., Parasite Immunol 2003
(Leishmaniasis, Cutaneous) :
Cross-talk between CD8 ( + ) and CD4 ( + ) T cells in experimental cutaneous leishmaniasis :
CD8 ( + ) T cells are
required for optimal
IFN-gamma production by CD4 ( + ) T cells
Kitchen et al., Proc Natl Acad Sci U S A 2004
(HIV Infections) :
Here, we report that the CD4 molecule
plays a direct role in
CD8 ( + ) T cell function by modulating expression of
IFN-gamma and Fas ligand, two important CD8 ( + ) T cell effector molecules
Sheth et al., AIDS 2004
(HIV Infections) :
We therefore examined the association between systemic HIV-specific
IFN-gamma CD8 responses and viral load in the semen and blood of HIV infected men
Edwards et al., Eur J Immunol 2005
(Cryptococcosis...) :
CD4 ( + ) and
CD8 ( + ) T cells producing
IFN-gamma increase in frequency, while those producing IL-5 decrease
Chen et al., Eur J Immunol 2005
(Dermatitis, Contact...) :
However, by contrast with CCL5/RANTES, the diminished levels of
IFN-gamma were likely
due to the decreased number of skin infiltrating
CD8 ( + ) T cells, since IFN-gamma production by antigen stimulated CD8 ( + ) T cells was comparable between wild-type and IL-15Ralpha ( -/- ) mice
Ramadan et al., Clin Exp Immunol 2005
:
Cytotoxic activity and
interferon (IFN)-gamma production were
mediated exclusively by
CD8 ( + ) T cells in response to pool pulsed targets
Miyagi et al., Clin Exp Immunol 2005
(Cryptococcosis...) :
The
IFN-gamma synthesis in BALF was
inhibited by depletion of
CD8 ( + ) and CD4 ( + ) T cells on days 7 and 14 after infection, respectively, but not by depletion of NK and gammadelta T cells
Gregori et al., J Exp Med 2005
:
Similarly,
CD8 ( + ) T cell lines specific for the influenza A matrix protein derived peptide ( MP.58-66 ) generated in the presence of chA6 mAb were anergic and
suppressed IFN-gamma production by MP.58-66-specific effector CD8 ( + ) T cells
Worgall et al., J Clin Invest 2005
(Pseudomonas Infections) :
AdZ.Epi8 induced Epi8-specific
IFN-gamma positive CD4 and
CD8 T cell
responses and resulted in protection against a lethal pulmonary challenge with agar encapsulated P. aeruginosa
Bekker et al., AIDS 2005
(Cytomegalovirus Infections...) :
Despite these increases, the CMV-specific
IFN-gamma producing
CD8 T cell
response was diminished, which could explain the inability to suppress CMV completely in 41 % of HIV-1 infected children
Suradhat et al., Vet Immunol Immunopathol 2005
(Classical Swine Fever) :
The CD4 ( - ) CD8 ( + ) cells were major IFN-gamma producing cells in vaccinated pigs, while both CD4 ( + ) CD8 ( + ) and CD4 ( - )
CD8 ( + ) populations
contributed to the
IFN-gamma production in the control group
Antonis et al., Vaccine 2006
(Respiratory Syncytial Virus Infections) :
Functional
IFN-gamma+ CD8 responses were slightly higher in the FI-bRSV vaccinated animals
Fogg et al., J Immunol 2006
(Herpesviridae Infections...) :
rhBZLF1-specific
IFN-gamma ELISPOT responses ranging between 56 and 3070 spot forming cells/10 ( 6 ) PBMC were detected in 36 of 57 ( 63 % ) rhesus macaques and were largely
mediated by
CD8 ( + ) T lymphocytes
Kapogiannis et al., AIDS Res Hum Retroviruses 2006
(HIV Infections...) :
Among untreated patients with increased viral load there was a constant IFN-gamma
CD8 response but a declining
IFN-gamma CD4
response
Ramirez-Montagut et al., J Immunol 2006
(Disease Progression...) :
Rejection requires CD4+,
CD8+ , and NK1.1+ cells and is
dependent on
IFN-gamma and Fas ligand and independent of perforin
Blachère et al., J Immunol 2006
:
Concerning the interaction between CD4 ( + ) T cells and DCs, we tested the hypothesis that CD40 engagement on DCs is critical for IL-12p70 ( IL-12 ) production and subsequent
stimulation of
IFN-gamma release by
CD8 ( + ) T cells
Yonkers et al., J Infect Dis 2006
(HIV Infections...) :
We measured CD4- and
CD8-specific interferon- gamma responses to hepatitis C virus ( HCV ) peptide pools in subjects with chronic HCV monoinfection ( n=14 ), in subjects with chronic HCV/HIV coinfection ( n=15 ), and in healthy control subjects ( n=10 ) by enzyme linked immunospot assay in the presence and absence of CD28 costimulation
Liu et al., J Immunol 2006
:
Overcoming original antigenic sin to generate new
CD8 T cell
IFN-gamma responses in an antigen experienced host
Fuse et al., J Virol 2006
:
During long-term immune surveillance, the virus-specific
CD8 ( + ) T cells were
impaired in
IFN-gamma production and secondary expansion and exhibited an altered phenotype
Alimonti et al., Immunol Cell Biol 2006
(HIV Infections) :
Overall, many of the HIV ( ES ) women possess a HIV-1 p24-specific
CD8+ IFN-gamma response , providing evidence to the specificity needed for an effective HIV vaccine
Kosaka et al., Cancer Sci 2006
:
The fact that IL-12 administration in vivo caused the generation of ASGM1 ( + )
CD8 ( + ) killer T cells in an
IFN-gamma dependent manner further indicated a physiological significance of ASGM1 ( + ) CD8 ( + ) central memory-type T cells in IL-12 induced immunoregulation for the therapy of tumors and infectious diseases
Ortega et al., Res Vet Sci 2007
(Chlamydophila Infections) :
An effective vaccine against C. abortus must induce a Th1-like specific immune response, which is characterized by the early production of
IFN-gamma and the
activation of
CD8 ( + ) T cells
Russell et al., J Acquir Immune Defic Syndr 2007
:
Net cumulative HIV-specific
CD8 IFNgamma ELISpot assay
responses were 13 % ( 95 % CI : -1 % to 26 % ) for recipients of vCP1452 alone and 16 % ( 95 % CI : 2 % to 29 % ) for recipients of vCP1452 plus rgp120
Hokeness et al., J Virol 2007
(Cytomegalovirus Infections) :
Furthermore, CXCR3 functions augmented the hepatic accumulation of
CD8 T-cell
IFN-gamma responses to MCMV
Dobaño et al., Mol Immunol 2007
(Malaria) :
Mutation of the P2 but not P9 or P10 anchor residues decreased protection and completely abrogated the antigen-specific CD8+ CTL activity and
CD8+ dependent
IFN-gamma responses to the immunodominant CD8+ epitope and overlapping CD8+/CD4+ epitope
Asavaroengchai et al., Biol Blood Marrow Transplant 2007
(Graft vs Host Disease) :
These data show that
IFN-gamma negatively
regulates the
CD8 T cell response by inhibiting cell division and promoting cell death and suggest that blockade of IFN-gamma could augment the severity of GVHD in patients undergoing allo-HCT
Rodriguez et al., J Gen Virol 2007
(Chronic Disease...) :
In vitro stimulation of whole-blood cultures with recombinant gp120 ( rgp120 )
resulted in enhanced
IFN-gamma production predominantly by the CD3 ( - )
CD8 ( + ) subset of NK cells, and addition of anti-IL-15 to the system decreased IFN-gamma production
Ngai et al., Infect Immun 2007
(Disease Models, Animal...) :
By using major histocompatibility complex class II-deficient or CD4-deficient mice, we found that the lack of CD4 T cells did not negatively affect primary or secondary
CD8 T-cell
IFN-gamma responses ... Moreover, during mycobacterial infection,
CD8 T-cell
IFN-gamma responses and activation are independent of CD4 T-cell activation
Osorio et al., Virus Res 2007
:
IFN-gamma expression by CD4 ( + ) T cells was
CD8 ( + ) T cells
dependent
McNicol et al., Eur J Immunol 2007
:
Using anti-CD8alpha and anti-CD8beta antibodies, we found that cytotoxicity and
IFN-gamma production by high but not by low avidity CTL was strongly
CD8 dependent
Spadaro et al., Cancer Res 2007
(Adenocarcinoma...) :
Thus, the inhibition of distant tumors by oral TLF seems to be mediated by an
IFN-gamma dependent enhancement of
CD8 ( + ) T- and NKT cell activity initiated within the intestinal mucosa
Messingham et al., J Immunol 2007
(Listeriosis) :
Whether
IFN-gamma contributes to the per-cell protective capacity of memory
CD8 ( + ) T cells against Listeria monocytogenes ( LM ) has not been formally tested
Isogai et al., Immunology 2007
(Asthma...) :
We have previously shown that
CD8 ( + ) gammadelta T cells decrease late allergic airway responses, airway eosinophilia, T helper 2 cytokine expression and
increase interferon-gamma (IFN-gamma) expression
Saha et al., J Immunol 2007
(Disease Susceptibility...) :
Both CD4 ( + ) and
CD8 ( + ) T cells were
involved in
IFN-gamma and IL-10 production
Niederkorn et al., Curr Opin Immunol 2008
(Multiple Sclerosis...) :
In many cases,
IFN-gamma is
required for either the induction or expression of
CD8 ( + ) T regs
Rifa'i et al., Int Immunol 2008
:
CD8 ( + ) CD122 ( + ) Treg effectively
suppressed the
IFN-gamma production of the target cells of syngeneic mouse strains but not of allogeneic mouse strains with incompatible MHC
Chakravarty et al., Infect Immun 2008
:
However, the requirement for
CD8 ( + ) T-cell
mediated IFN-gamma production in protective immunity to this pathogen has not been directly tested
Wells et al., J Immunol 2008
(Melanoma, Experimental) :
Immunization with two or more TLR agonists, anti-CD40,
IFN-gamma , and surfactant were
sufficient to drive unprecedented levels of
CD8 response to peptide or protein Ag and highly polarized Th1 CD4 responses
Björck et al., J Immunol 2008
:
IC-loaded pDC stimulate CD4 ( + ) T cells to proliferate and secrete a mixture of IL-4 and IFN-gamma, and they
induce CD8 ( + ) T cells to secrete IL-10 as well as
IFN-gamma ... In contrast, IC-loaded myDC
induce both CD4 ( + ) and
CD8 ( + ) T cells to secrete mainly
IFN-gamma
Kutscher et al., AIDS research and therapy 2008
:
The intracellular detection of MIP-1beta enhances the capacity to detect
IFN-gamma mediated HIV-1-specific
CD8 T-cell
responses in a flow cytometric setting providing a sensitive alternative to the ELISPOT
Apte et al., Proc Natl Acad Sci U S A 2008
:
Interferon-gamma and interleukin-4 reciprocally
regulate CD8 expression in CD8+ T cells
Onishi et al., Br J Urol 1991
(Kidney Neoplasms) :
The effect of
IFN-gamma on TIL was an
increase in CD3 ( pan-T cells ), especially an increase in
CD8 ( cytotoxic/suppressor-T cells )
Balkow et al., Exp Dermatol 2009
:
When compared with untreated DC or DC treated with anti-CD40 alone, DC matured with anti-CD40 plus IL-12 and IL-18 expressed significantly more
IFN-gamma and IL-12,
induced enhanced
CD8 ( + ) T-cell proliferation, prolonged synaptic interaction with T cells and increased CD8 ( + ) T-cell mediated cytotoxicity
Rutenfranz et al., Scand J Immunol 1991
:
In further studies, depletion of T-cell subsets showed that CD3+, CD4+,
CD8+ , CD29+ and CD45RA+ cells were
involved in
IFN-gamma production after mitogenic stimulation
Ascon et al., Kidney Int 2009
(Kidney Diseases...) :
Depletion of CD4 ( + ) and
CD8 ( + ) T cells before ischemia
caused less medullary damage and reduced kidney
IFN-gamma expression, whereas their depletion following ischemia increased kidney IL-1beta ; however, depletion of these cells had no effect on histological damage to the kidney
Robinson et al., J Immunol 2009
(Disease Models, Animal...) :
We conclude that liver damage in this model of fulminant autoimmune hepatitis is driven by CD4 ( + ) T cell production of
IFN-gamma , is
independent of both
CD8 ( + ) T cells and the Fas ligand/Fas pathway, and is not explained by a lack of PD-L1 expression
Liu et al., J Virol 2009
(Disease Models, Animal...) :
In addition, M ( 209-223 ) peptide activated CD4 T cells reduced
IFN-gamma and IL-2 production in M- and M2-specific
CD8 T-cell
responses to D ( b ) -M ( 187-195 ) and K ( d ) -M2 ( 82-90 ) peptides more than M2 ( 25-39 ) peptide stimulated CD4 T cells
Komai-Koma et al., Eur J Immunol 2009
:
Moreover,
CD8 ( + ) CD45RO ( + ) memory T cells constitutively expressed TLR4 and markedly
enhanced IFN-gamma production when stimulated with LPS
Wong et al., J Immunol 2009
:
IL-12p70 production was produced predominantly by
CD8alpha ( + ) DCs and plasmacytoid DCs, and
mediated by CD8 T cell derived cytokines
IFN-gamma , GM-CSF, TNF-alpha, and surface CD40L
Takeda et al., J Immunol 2009
(Asthma...) :
Using adoptive transfer experiments, we found that suppression of AHR was mediated by Ag-specific
CD8 ( + ) T cells and was
dependent on
IFN-gamma production by the transferred T cells
Yuan et al., Eur J Cancer Prev 2009
(Breast Neoplasms) :
We also found that CD4 positive and
CD8 positive lymphocytes were detected only in tumors grown in rBCG-MVNTR4/8-CSF immunized animals, and strong
IFN-gamma responses were
induced by immunization with rBCG-MVNTR4-CSF and rBCG-MVNTR8-CSF vaccines
Todryk et al., Immunology 2009
:
We observed a significant correlation between
IFN-gamma responses to CD4-stimulatory, but not to
CD8-stimulatory , recall antigens measured by these assays, suggesting a divergence in regulation
Park et al., J Leukoc Biol 2009
(Alveolitis, Extrinsic Allergic) :
Moreover, IL-10 production of CD4 ( + ) CD25 ( + ) T ( reg ) cells and direct contact between CD4 ( + ) CD25 ( + ) T ( reg ) cells and CD4 ( + ) or
CD8 ( + ) T cells in BALF
resulted in reduced
IFN-gamma production
Tuettenberg et al., Exp Dermatol 2010
:
Furthermore, stimulation of
CD8 ( + ) T cells by peptide loaded CD40L-DC
resulted in a substantial reduction of antigen-specific
IFN-gamma production
Sercan et al., J Immunol 2010
(Lymphopenia) :
Although its antimicrobial effector functions are well described, less is known about the mechanisms by which
IFN-gamma regulates
CD8 ( + ) T cell homeostasis
Freeman et al., J Immunol 2010
(Pulmonary Disease, Chronic Obstructive) :
In vitro stimulation of lung
CD8 ( + ) T cells with IL-18 plus IL-12 markedly
increased production of
IFN-gamma and TNF-alpha, whereas IL-15 stimulation induced increased intracellular perforin expression
Contreras et al., J Immunol 2010
:
Compared to CD26 ( - ) DCs, the sheep CD26 ( + ) DCs show 1 ) potent
stimulation of allogeneic naive
CD8 ( + ) T cells with high selective induction of the
Ifngamma and Il22 genes ; 2 ) dominant efficacy in activating specific CD8 ( + ) T cells against exogenous soluble Ag ; and 3 ) selective expression of functional pathways associated with high capacity for Ag cross-presentation
Hodgkin et al., Cell Immunol 1990
:
Interferon-gamma (IFN-gamma) caused almost complete inhibition of the
CD4+/CD8- response but had no measurable effect on the growth of CD4-/CD8+ or CD4-/CD8- populations
Connick et al., J Acquir Immune Defic Syndr 2011
(HIV Infections) :
HIV-specific
CD8+ interferon-gamma responses increased after 48 weeks of ART ( P = 0.03 ), but failed to predict virologic success ( P = 0.18 )
Brisbin et al., Benef Microbes 2012
:
The results demonstrated that chicken CD4+ and
CD8+ T-cells express TLR21 and that the various isolates of lactobacilli differentially
induces the expression of interleukin 10,
interferon-gamma and transforming growth factor beta
Siegel et al., Cell Immunol 1988
:
It is concluded that ( i )
IFN-gamma augmented activation of T cells in human MLC, ( ii ) IFN-gamma exerted effects directly on T cells, and ( iii ) IFN-gamma preferentially
augmented CD8+ cell activation
Dieli et al., J Immunol 1997
(Dermatitis, Contact) :
In fact, the production of
IFN-gamma was
due to a
CD8+ , gamma delta+ T cell, while proliferation and IL-2 production required the presence of a CD4+, alpha beta+ T cell
Dieli et al., Cytokine 1996
:
This production of
IFN-gamma is both antigen-specific and genetically ( MHC ) -restricted and is
due to both
CD8+ and CD4+ T cells
Vaidya et al., J Exp Med 1997
:
Here, we isolate the gene for TLTF and demonstrate that the recombinant version of TLTF specifically
induces CD8 ( + ), but not CD4 ( + ), T cells to secrete
IFN-gamma
Connelly et al., Infect Immun 1997
(Malaria) :
The dominance of type 1
CD8 cell
IFN-gamma responses is consistent with a role for this T-cell population in immunity to liver-stage Plasmodium falciparum in humans
Su et al., J Immunol 1998
(Lymphocytic Choriomeningitis) :
CD4+ and
CD8+ T cell interactions in
IFN-gamma and IL-4
responses to viral infections : requirements for IL-2