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HMGB1 — IFNG

Text-mined interactions from Literome

Wang et al., Surgery 1999 : Interferon gamma alone did not induce the release of HMG-1 , but it enhanced TNF induced HMG-1 release
Rendon-Mitchell et al., J Immunol 2003 : IFN-gamma induces high mobility group box 1 protein release partly through a TNF dependent mechanism ... IFN-gamma , an immunoregulatory cytokine known to mediate the innate immune response, dose-dependently induced the release of HMGB1 , TNF, and NO, but not other cytokines such as IL-1alpha, IL-1beta, or IL-6 ... Pharmacological suppression of TNF activity with neutralizing Abs, or genetic disruption of TNF expression ( TNF knockout ) partially ( 50-60 % ) inhibited IFN-gamma mediated HMGB1 release ... AG490, a specific inhibitor for Janus kinase 2 of the IFN-gamma signaling pathway, dose-dependently attenuated IFN-gamma induced HMGB1 release ... These data suggest that IFN-gamma plays an important role in the regulation of HMGB1 release through a TNF- and Janus kinase 2-dependent mechanism
DeMarco et al., Mol Immunol 2005 : Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1 ... Here we show that HMGB1 enhances interferon gamma release from macrophage ( but not dendritic cell ) -stimulated NK cells
Yin et al., Shock 2005 (Inflammation...) : Furthermore, it has been reported that IFN-gamma stimulates the release of HMGB1 from macrophages ... Our studies showed that inhibition of IFN-gamma activity in vivo reduced the levels of HMGB1 in peritoneal fluid and serum of CLP rats 24 h after surgery
Wähämaa et al., J Leukoc Biol 2007 : IFN-gamma already induced substantial HMGB1 secretion from the monocytic cell line RAW 264.7 within 24 h and even more so after 48 h. LPS only stimulated a modest HMGB1 release within 24 h, but this increased considerably by 48 h. TNF induced HMGB1 release was unexpectedly low
Kim et al., Mol Med 2013 : HMGB1 induces the release of monocyte chemotactic protein 1 (MCP-1), interferon gamma induced protein 10 ( IP-10 ) and macrophage inflammatory protein 1a ( MIP-1a ) in a TLR4- and CD14 dependent manner
Zhang et al., Zhongguo Ying Yong Sheng Li Xue Za Zhi 2013 : IFN-gamma up-regulated the expression of HMGB1 , SREBP-1, FAS mRNA and protein time-dependently ; Transfection of MMC with HMGB1 siRNA resulted in the suppression of SREBP-1, FAS protein levels induced by IFN-gamma, following with decrease of lipid deposition