Kawamura et al., Blood 2000
(Multiple Myeloma) :
In studies of apoptosis associated proteins, BMP-2 was seen to down-regulate the expression of Bcl-x ( L ) ; however, BMP-2 had no effects on the expression of Bcl-2, Bax , or Bad
Eliseev et al., Oncogene 2008
(Bone Neoplasms...) :
Furthermore, bone morphogenetic protein induced or vector mediated expression of Runx2 resulted in upregulation of Bax expression, and subsequent increased sensitivity of Saos2 cells to apoptosis