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IKBKB — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Fujioka et al., J Biol Chem 2004
:
Importantly, lack of RelA,
IKK , and p53 as well as expression of a dominant negative IkappaBalpha ( IkappaBalphaM )
inhibited NF-kappaB dependent
p53 activation and apoptosis
Jeong et al., J Biol Chem 2005
:
A novel NF-kappaB pathway
involving IKKbeta and p65/RelA Ser-536 phosphorylation results in
p53 Inhibition in the absence of NF-kappaB transcriptional activity ... We now present evidence that suggests that the upstream kinase
IKKbeta plays an important role in Tax induced
p53 inhibition through phosphorylation of p65/RelA at Ser-536
Kawauchi et al., Proc Natl Acad Sci U S A 2009
:
Loss of
p53 enhances catalytic activity of
IKKbeta through O-linked beta-N-acetyl glucosamine modification
Yang et al., J Cell Mol Med 2010
(Neoplasm Metastasis...) :
Loss of
IKKbeta activity
increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis ...
IKKbeta inhibitors can
increase the protein stability, nuclear accumulation and promoter binding activity of
p53 , leading to the p21 gene transcription
Suzuki et al., PloS one 2011
:
p53 inhibits not only the catalytic activity of
IKK2 presumably through the modulation of glycosylation but also p65 ( RelA ) -mediated transactivation
Jia et al., Cell Death Differ 2013
:
IKK-ß and p85 S6K1
contributed to H ( 2 ) O ( 2 ) -induced phosphorylation of Mdm2 ( S166 ) and
p53 accumulation