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MMP9 — TP53
Text-mined interactions from Literome
Sun et al., Mol Carcinog 1999
(Neoplasm Metastasis) :
p53 transcriptionally
activates expression of the genes encoding epidermal growth factor receptor,
matrix metalloproteinase (MMP)-2 , cathepsin D, and thrombospondin-1 but represses expression of the genes encoding basic fibroblast growth factor and multidrug resistance-1
Cohen et al., Hum Reprod 2008
:
Regulation of
MMP-9 by
p53 in first trimester cytotrophoblastic cells ... Because of p53 overexpression in trophoblastic cells, and its potential role in regulating MMP-2 and MMP-9 expression in different cell lines, we hypothesized that the expression of
MMP-9 could also be
regulated by
p53 in first trimester cytotrophoblasts (CTB)
Yan et al., Exp Neurol 2008
(Brain Edema...) :
This can be at least partially ascribed to
p53 inducing a significant up-regulation of
MMP-9 via NF-kappaB in the endothelium, which in turn opened the tight junction by degrading Occludin and disrupting the basal lamina by degrading collagen IV
Xiao et al., J Cell Biochem 2009
(Melanoma) :
Cytoprotective effects of the lipoidic-liquiform pro-vitamin C tetra-isopalmitoyl-ascorbate ( VC-IP ) against ultraviolet-A ray induced injuries in human skin cells together with collagen retention,
MMP inhibition and
p53 gene repression