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IRS1 — TRIM72

Text-mined interactions from Literome

Song et al., Nature 2013 (Diabetes Mellitus, Type 2...) : Here we show in mice that muscle-specific mitsugumin 53 ( MG53 ; also called TRIM72 ) mediates the degradation of the insulin receptor and insulin receptor substrate 1 (IRS1) , and when upregulated, causes metabolic syndrome featuring insulin resistance, obesity, hypertension and dyslipidaemia
Yi et al., Nature communications 2013 : Mitsugumin 53 (MG53) negatively regulates skeletal myogenesis by targeting insulin receptor substrate 1 (IRS-1)