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IL15 — IRAK1
Text-mined interactions from Literome
Jensen et al., J Biol Chem 2001
(Carcinoma, Hepatocellular...) :
IRAK1b , a novel alternative splice variant of interleukin-1 receptor associated kinase ( IRAK ),
mediates interleukin-1 signaling and has prolonged stability
Kim et al., J Biol Chem 2005
(Inflammation) :
Importantly, endogenous
mPLK/IRAK was activated in
response to TNF-alpha or
interleukin 1 treatment of primary adipose cells
Ahmad et al., Blood 2008
:
Altogether, these results unequivocally show that HSV-1 induces TLR2 dependent activation of
IL-15 gene expression, which requires the recruitment of both MyD88 and TIRAP/Mal and the
activation of
IRAK1 and TRAF6 leading to NF-kappaB translocation to the nucleus