Gene interactions and pathways from curated databases and text-mining

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ADCYAP1 — FOS

Text-mined interactions from Literome

Nagashima et al., Mol Cell Endocrinol 2003 (Pituitary Neoplasms) : Accordingly, PACAP stimulated AP-1 and CREB transcriptional activity and E ( 2 ) inhibited TRE-LUC but not CRE-LUC activation
Falktoft et al., Neuropeptides 2009 (Neuroblastoma) : Calmodulin interacts with PAC1 and VPAC2 receptors and regulates PACAP induced FOS expression in human neuroblastoma cells ... The immediate early response gene FOS is a well-known marker of neuronal activation, so we used a human neuroblastoma cell line NB-1 to explore the role of calmodulin in PACAP induced FOS gene expression ... We observed both short-term and prolonged altered PACAP mediated activation of the FOS gene in the presence of the calmodulin-antagonist W-7
Falktoft et al., Neuropeptides 2009 (Neuroblastoma) : PACAP also enhanced the FOS gene expression and individual presence of H-89, BIS, Gö6976 and U0126 partially attenuated the PACAP induced FOS mRNA expression ... The resemblance of the signaling pathways involving concomitant activities of PKC, ERK1/2 and PKA in PACAP regulation of the FOS and VIP gene expressions suggest for the first time a role of FOS in PACAP induced VIP gene expression in human NB-1 neuroblastoma cells
Yi et al., Diabetes 2010 : In the hypothalamus, Fos immunoreactivity induced by PACAP-38 was colocalized within autonomic neurons in paraventricular nuclei projecting to preganglionic sympathetic neurons in the spinal cord
Schäfer et al., Eur J Biochem 1996 : Both PACAP ( 1-27 ) -peptide and PACAP- ( 1-38 ) -peptide strongly increased the DNA binding activity of the c-fos/ c-jun heterodimer transcription factor AP-1 at 10 nM and also stimulated AP-1 transcriptional activity up to 20-fold in AR4-2J cells