von Figura et al., Curr Opin Cell Biol 1991
(Mucolipidoses) :
Recent studies have established that in mammalian cells insulin-like growth factor-II can couple the large mannose-6-phosphate receptor to a GTP binding protein and that the insulin-like growth factor-II induced activation of the GTP binding protein is inhibited by mannose-6-phosphate and lysosomal enzymes
Zhang et al., Proc Natl Acad Sci U S A 1997
:
The effect of IGF-II was evoked at nonstimulatory concentrations of glucose, was mediated by a pertussis toxin sensitive GTP binding protein , was dependent on protein kinase C-induced phosphorylation, and was independent of changes in cytoplasmic free Ca2+ concentration