Gene interactions and pathways from curated databases and text-mining

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MAPK1 — XIAP

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: XIAP → MAPK1 (increases)
    Evidence: Treatment of melanoma cells with either TRAIL or U0126, a MEK inhibitor could not induce significant reduction in XIAP expression levels, but when the agents were combined there was marked decrease in the percentage of XIAP-positive cells, suggesting that TRAIL-induced XIAP was upregulated by ERK2.

Text-mined interactions from Literome

Cipak et al., Neoplasma 2012 (Leukemia...) : Inhibitors of JNK ( SP600125 ) and p38 MAPK ( SB203580 ) suppressed HEAMQ induced apoptosis and G2/M phase arrest, attenuated the activation of Bax, and blocked down-regulation of Bcl-2, XIAP and survivin in HEAMQ treated U937 cells
Fadó et al., Scientific reports 2013 (MAP Kinase Signaling System) : The effects of XIAP are mediated by the mitogen activated protein kinase ( MEK ) /extracellular signal regulated kinases ( ERKs ) pathway since blocking this pathway completely prevents the neuritogenesis mediated by XIAP downregulation