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MAPK1 — XIAP
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
XIAP
→
MAPK1
(increases)
Evidence: Treatment of melanoma cells with either TRAIL or U0126, a MEK inhibitor could not induce significant reduction in XIAP expression levels, but when the agents were combined there was marked decrease in the percentage of XIAP-positive cells, suggesting that TRAIL-induced XIAP was upregulated by ERK2.
Text-mined interactions from Literome
Cipak et al., Neoplasma 2012
(Leukemia...) :
Inhibitors of JNK ( SP600125 ) and p38
MAPK ( SB203580 ) suppressed HEAMQ induced apoptosis and G2/M phase arrest, attenuated the activation of Bax, and
blocked down-regulation of Bcl-2,
XIAP and survivin in HEAMQ treated U937 cells
Fadó et al., Scientific reports 2013
(MAP Kinase Signaling System) :
The effects of
XIAP are
mediated by the
mitogen activated protein kinase ( MEK ) /extracellular signal regulated kinases ( ERKs ) pathway since blocking this pathway completely prevents the neuritogenesis mediated by XIAP downregulation