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CXCR3 — IL6
Text-mined interactions from Literome
Venza et al., J Periodontol 2010
(Chronic Periodontitis...) :
These findings showed that : 1 ) in subjects without diabetes and patients with well controlled diabetes, TNF-alpha, CCR5, and
CXCR3 may constitute distinctive biomarkers of P-IM; 2 ) poor glycemic control abolished the differences between CP and P-IM regarding the expression of these mediators ; and 3 ) type 2 diabetes
affected the expression of TNF-alpha,
IL-6 and -8, CCR5, and CXCR3
Schmitz et al., Brain Behav Immun 2013
:
Oppositely,
CXCR3-deficiency had no protective effect after traumatic nerve injury but reduced EAE evoked hyperalgesia and was associated with reduced clinical EAE scores, a reduction of the pro-inflammatory cell infiltration and
reduced upregulation of interferon gamma and
interleukin-17 in the spinal cord