Gene interactions and pathways from curated databases and text-mining

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CXCR3 — IL6

Text-mined interactions from Literome

Venza et al., J Periodontol 2010 (Chronic Periodontitis...) : These findings showed that : 1 ) in subjects without diabetes and patients with well controlled diabetes, TNF-alpha, CCR5, and CXCR3 may constitute distinctive biomarkers of P-IM; 2 ) poor glycemic control abolished the differences between CP and P-IM regarding the expression of these mediators ; and 3 ) type 2 diabetes affected the expression of TNF-alpha, IL-6 and -8, CCR5, and CXCR3
Schmitz et al., Brain Behav Immun 2013 : Oppositely, CXCR3-deficiency had no protective effect after traumatic nerve injury but reduced EAE evoked hyperalgesia and was associated with reduced clinical EAE scores, a reduction of the pro-inflammatory cell infiltration and reduced upregulation of interferon gamma and interleukin-17 in the spinal cord