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CA2 — NUP62
Text-mined interactions from Literome
Jan et al., Chin J Physiol 2000
(Carcinoma, Transitional Cell...) :
This report demonstrates that
NPC-15199 [ ( N- ( 9-fluorenylmethoxycarbonyl ) L-leucine ) ], a novel anti-inflammatory agent,
increases intracellular
Ca2+ concentration ([Ca2+]i) in human bladder female transitional cancer ( BFTC ) cells ... In Ca2+-free medium, pretreatment with 1 mM NPC-15199 abolished the [ Ca2+ ] i increase induced by 1 microM thapsigargin ( an endoplasmic reticulum Ca2+ pump inhibitor ) ; and after pretreatment with thapsigargin,
NPC-15199 induced
Ca2+ release was dramatically inhibited ... Together, the findings suggest that in BFTC bladder cancer cells,
NPC-15199 induced
Ca2+ release from the endoplasmic reticulum and activating Ca2+ entry
Jan et al., Life Sci 2003
(Calcium Signaling...) :
Effect of
NPC-14686 ( Fmoc-L-homophenylalanine ) on intracellular
Ca2+ levels in human hepatoma cells
Jan et al., Chin J Physiol 2002
:
Effect of
NPC-15199 on
Ca2+ levels in renal tubular cells ... In Madin-Darby canine kidney ( MDCK ) cells,
effect of
NPC-15199 on intracellular
Ca2+ concentration ([Ca2+]i) was investigated by using fura-2 ... These results suggest that
NPC-15199 rapidly
increases [
Ca2+ ] i by stimulating both extracellular Ca2+ influx and intracellular Ca2+ release via as yet unidentified mechanism ( s )
Huang et al., Life Sci 2006
(Calcium Signaling...) :
The
effect of
NPC-14686 , a potential anti-inflammatory drug, on cytosolic free
Ca2+ levels ( [ Ca2+ ] i ) and growth in PC3 human prostate cancer cells was examined by using fura-2 as a fluorescent Ca2+ indicator and WST-1 as a fluorescent growth dye ...
NPC-14686 at concentrations above 10 microM
increased [Ca2+ ] i in a concentration dependent manner with an EC50 value of 100 microM ... Pretreatment with 1 microM thapsigargin ( an endoplasmic reticulum Ca2+ pump inhibitor ) to deplete the endoplasmic reticulum Ca2+ nearly abolished 200 microM
NPC-14686 induced
Ca2+ release ; and conversely pretreatment with NPC-14686 completely inhibited thapsigargin induced Ca2+ release ... The
Ca2+ release
induced by 200 microM
NPC-14686 was not affected by inhibiting phospholipase C with 2 microM U73122