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GSK3B — NOTCH2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: GSK3B — NOTCH2 (physical association, affinity chromatography technology) Espinosa et al., J Biol Chem 2003*
• IRef Biogrid Interaction: GSK3B — NOTCH2 (direct interaction, enzymatic study) Espinosa et al., J Biol Chem 2003*
• IRef Biogrid Interaction: GSK3B — NOTCH2 (direct interaction, pull down) Espinosa et al., J Biol Chem 2003*
• IRef Ophid Interaction: NOTCH2 — GSK3B (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Espinosa et al., J Biol Chem 2003 : Consistent with this, GSK-3 beta inhibits the transcriptional activation of Notch target genes both in vitro and in vivo, whereas lithium chloride treatment or Wnt-1 overexpression that results in GSK-3 beta inhibition leads to the up-regulation of the Hes-1 promoter ... Together, our results suggest that cross-talk between Notch and Wnt pathways may be partially mediated by specific regulation of GSK-3 beta dependent Notch phosphorylation
Guha et al., Basic Res Cardiol 2011 (Neointima) : Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells : role in cell proliferation and survival