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CDK1 — EPHB2

Text-mined interactions from Literome

Alldridge et al., Exp Cell Res 2003 (MAP Kinase Signaling System) : Moreover, ANXA1 reduces proliferation by ERK mediated disruption of the actin cytoskeleton and ablation of cyclin D1 protein expression and not by ERK mediated induction of the cyclin dependent kinase , CDK2, inhibitor p21 ( cip/waf )
Dangi et al., J Biol Chem 2005 : We show that Cdc2 inhibits EGF mediated ERK activation through direct interaction and phosphorylation of several ERK pathway proteins, including the guanine nucleotide exchange factor, Sos-1, and Raf-1 kinase ... Inhibition of Cdc2 activity with roscovitine in mitotic cells restored ERK activation by EGF and PMA ... These data suggest that Cdc2 inhibits growth factor receptor mediated ERK activation during mitosis by primarily targeting signaling proteins that are upstream of MEK1
Minelli et al., Peptides 2006 : It greatly enhances the phosphorylation of hsp27, alpha-B-crystallin, Cdc2 , and p-38 MAPK, whereas it decreases the phosphorylation of MEK1, Cav 2, GSK3a, PKB/Akt, PKCdelta, PKCgamma, and Erk2
Kobayashi et al., J Biol Chem 2007 : Immunoblotting demonstrated that phosphorylation at this site was maximal in cells in G2/M phase, was enhanced by tumor necrosis factor-alpha related apoptosis inducing ligand ( TRAIL ) treatment, was blocked by inhibitors of CDK ( but not ERK or glycogen-synthase kinase 3beta ), and was stimulated in vitro by CDK 1 , CDK2, and JNK1
Bisel et al., J Cell Biol 2008 : ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65
Wang et al., Oncol Rep 2010 (Carcinoma, Hepatocellular...) : Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK, p-p38, p-p53 and p21, elevated the level of cyclin B1/p-Cdc2 ( Tyr15 ) complex, and inhibited the expression of p-ERK
Saito et al., J Exp Med 2010 (Cell Transformation, Neoplastic...) : In nonpolarized epithelial cells, Erk activation results in oncogenic stress, up-regulation of the p21 ( Waf1/Cip1 ) cyclin dependent kinase inhibitor, and induction of senescence
Hong et al., Exp Cell Res 2011 (Prostatic Neoplasms) : Ectopic expression of a constitutively active AR inhibited Raf/MEK/ERK mediated regulation of the differentiation markers, neuron-specific enolase and neutral endopeptidase, and the cyclin dependent kinase inhibitors, p16(INK4A) and p21 ( CIP1 ), but not Rb phosphorylation and E2F1 expression, indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling
Colello et al., J Biol Chem 2012 (MAP Kinase Signaling System) : Integrins regulate microtubule nucleating activity of centrosome through mitogen activated protein kinase/extracellular signal regulated kinase kinase/extracellular signal regulated kinase ( MEK/ERK ) signaling