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EPHB2 — GRM1

Text-mined interactions from Literome

Ferraguti et al., Eur J Neurosci 1999 : In particular, mGluR1a and mGluR2 preferentially mediated phosphorylation and activation of ERK2 in a pertussis toxin ( PTX ) -sensitive and concentration dependent manner ... Furthermore, mGluR1a mediated ERK activation was suppressed by the depletion of endogenous protein kinase C ( PKC ) activity and by the PKC inhibitors staurosporine and calphostin C, but not chelerythrine
Karim et al., J Neurosci 2001 (Inflammation) : We show that activation of mGluR1 and mGluR5 leads to activation of ERK1 and ERK2 in the spinal cord
Mao et al., J Neurosci 2005 (MAP Kinase Signaling System) : We found that selective activation of mGluR5, but not mGluR1 , increased ERK1/2 phosphorylation
Page et al., Neurochem Int 2006 : In addition, the p70S6K ( Thr421/Ser424 ) activation via the ERK1/2 activation is increased and involved also mGluR1 receptors
Zhang et al., FEBS Lett 2008 : Deletion of mGluR1a-carboxyl terminus ( CT ) or mutation of Leu to Ala in the CT of mGluR1a reduces the association, indicating the essential binding region of mGluR1a for CAL. Functionally, the interaction of mGluR1a with CAL was shown to inhibit mGluR1a mediated ERK1/2 activation, without an apparent effect, via the C-terminal truncated receptor
Nicodemo et al., Molecular brain 2010 : The activation of endogenous mGluR1 in primary mouse cortical neuron stimulates ERK1/2 phosphorylation