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EPHB2 — KLF5

Text-mined interactions from Literome

Yang et al., FASEB J 2007 (MAP Kinase Signaling System) : We show that Klf5 increases proliferation, transcriptionally up-regulates EGFR, and activates MEK/ERK signaling, as indicated by increased phosphorylation of MEK and ERK ... Thus, Klf5 regulates MEK/ERK signaling via EGFR and is also downstream of MAPK signaling, providing a novel mechanism for signal amplification or suppression and control of proliferation in basal cells
Liu et al., J Biol Chem 2009 (Breast Neoplasms) : Finally, the activation of ERK by KLF5 is very likely through the KLF5 direct target gene FGF-BP in breast cells
He et al., J Biochem 2009 (MAP Kinase Signaling System) : These results suggest that Ang II induces KLF5 phosphorylation mediated by the ERK signalling in VSMCs, which in turn stimulates the interaction of KLF5 with c-Jun, subsequently leads to the suppression of p21 expression
Mori et al., Mol Cancer Res 2009 (Pancreatic Neoplasms) : Surprisingly, inhibition of B-Raf/C-Raf or MAPK/Erk did not reduce KLF5 levels, suggesting that KLF5 expression is not promoted by KRAS-Raf-MEK-Erk signaling in pancreatic cancer ... This finding is in striking contrast to reports on MEK-Erk mediated KLF5 induction in colon cancer cells ... In conclusion, overexpression of KLF5 in human pancreatic cancer cells is not mediated by KRAS/Raf/MAPK/Erk signaling, but involves the IL-1beta/IL-1R system, p38, and the transcription factor HIF-1alpha