◀ Back to MAPK9
MAP2K4 — MAPK9
Pathways - manually collected, often from reviews:
-
BioCarta mapkinase signaling pathway:
MKK7/MEK4 (MAP2K7/MAP2K4)
→
JNK1/MAPK9/MAPK10 (MAPK10/MAPK8/MAPK9)
(modification, activates)
-
KEGG Toll-like receptor signaling pathway:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, phosphorylation)
-
KEGG Fc epsilon RI signaling pathway:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG GnRH signaling pathway:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG Epithelial cell signaling in Helicobacter pylori infection:
MAP2K4
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG Chagas disease (American trypanosomiasis):
MAP2K4
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG MAPK signaling pathway:
MAP2K4
→
MAPK10/MAPK8/MAPK9
(protein-protein, phosphorylation)
-
KEGG Influenza A:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG ErbB signaling pathway:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
NCI Pathway Database ErbB1 downstream signaling:
JNK1-2 (MAPK8/MAPK9)
→
MKK4 (MAP2K4)
(modification, collaborate)
Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Coso et al., Cell 1995*, Minden et al., Cell 1995*, Minden et al., Science 1994, Fanger et al., EMBO J 1997*, Clarke et al., Mol Cell Biol 1998*, Pomérance et al., J Biol Chem 1998*
Evidence: assay
-
NCI Pathway Database Signaling events mediated by focal adhesion kinase:
JNK1-2 (MAPK8/MAPK9)
→
MKK4 (MAP2K4)
(modification, collaborate)
Oktay et al., J Cell Biol 1999, Almeida et al., J Cell Biol 2000*, Dolfi et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype
-
NCI Pathway Database CD40/CD40L signaling:
JNK family (MAPK8/MAPK9/MAPK10)
→
MKK4 (MAP2K4)
(modification, collaborate)
Hostager et al., J Biol Chem 2000, Haxhinasto et al., J Immunol 2002, Jabara et al., Immunity 2002, Gallagher et al., Nat Immunol 2007
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database PDGFR-beta signaling pathway:
MKK4-MKK7 (MAP2K7/MAP2K4)
→
JNK family (MAPK8/MAPK9/MAPK10)
(modification, activates)
Chiariello et al., Nat Cell Biol 2001, Zhao et al., J Exp Med 2001, Furstoss et al., EMBO J 2002, Iavarone et al., J Biol Chem 2003, Boureux et al., J Cell Sci 2005
Evidence: mutant phenotype, assay
-
Reactome Reaction:
MAPK9
→
MAP2K4
(reaction)
Sato et al., Nat Immunol 2005, Wang et al., Mol Cell Biol 2007*, Deacon et al., J Biol Chem 1997
-
WikiPathways Structural Pathway of Interleukin 1 (IL-1):
MAP2K4
→
MAPK8/MAPK9/MAPK10
(activation)
-
WikiPathways Wnt Signaling Pathway and Pluripotency:
MAP2K4
→
MAPK10/MAPK9
(mim-stimulation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MAP2K4
—
MAPK9
(direct interaction, two hybrid)
Vinayagam et al., Science signaling 2011
-
IRef Biogrid Interaction:
MAP2K4
—
MAPK9
(physical association, affinity chromatography technology)
Li et al., Toxicol Lett 2012*
-
IRef Biogrid Interaction:
MAP2K4
—
MAPK9
(direct interaction, pull down)
Ho et al., J Biol Chem 2003
-
IRef Hprd Interaction:
Complex of 26 proteins
(in vivo)
Figueroa et al., J Biol Chem 2003
-
IRef Hprd Interaction:
MAP2K4
—
MAPK9
(in vitro)
Fleming et al., Biochem J 2000*
-
IRef Hprd Interaction:
MAP2K4
—
MAPK9
(in vivo)
Fleming et al., Biochem J 2000*
-
IRef Innatedb Interaction:
MAP2K4
—
MAPK9
(unknown, -)
Mooney et al., J Biol Chem 2004*
-
IRef Innatedb Interaction:
MAP2K4
—
MAPK9
(unknown, -)
Chan-Hui et al., Biochem J 1998*
-
IRef Innatedb Interaction:
MAP2K4
—
MAPK9
(unknown, -)
Ho et al., J Biol Chem 2003
-
IRef Intact Interaction:
MAP2K4
—
MAPK9
(physical association, two hybrid)
Vinayagam et al., Science signaling 2011
-
IRef Ophid Interaction:
MAP2K4
—
MAPK9
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Martel-Pelletier et al., Arthritis Rheum 1999
(Osteoarthritis) :
Within minutes, IL-17 induced the phosphorylation of
mitogen activated protein kinase kinase-1/2 ( MEK-1/2 ), -3/6 ( MKK-3/6 ), p44/42, p38, and inhibitor of nuclear factor kappaB ( I kappaB)-alpha, as well as the
activation of
mitogen activated protein kinase activated protein kinase-1 and -2 ( MAPKAPK-1 and -2 )
Tu et al., J Biomed Sci 2001
(Carcinoma, Hepatocellular) :
On the other hand, PD98059, a specific inhibitor of
mitogen activated protein kinase kinase ,
blocks TPA induced
MAPK activation but has no effect on TPA induced tyrosine phosphorylation
Huang et al., Biochem Biophys Res Commun 2003
:
MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a
mitogen activated protein kinase kinase ( MAP2K ), which in turn
activates a
mitogen activated protein kinase ( MAPK )
Fanning et al., J Biol Chem 2003
(MAP Kinase Signaling System...) :
Mechanical compression induced a phased phosphorylation of ERK consisting of a rapid induction of ERK1/2 phosphorylation at 10 min, a rapid decay, and a sustained level of ERK2 phosphorylation that persisted for at least 24 h. Mechanical compression also
induced the phosphorylation of p38
MAPK in strictly a transient fashion, with maximal phosphorylation occurring at 10 min. Mechanical compression stimulated
SEK1 phosphorylation, with a maximum at the relatively delayed time point of 1 h and with a higher amplitude than ERK1/2 and p38 MAPK phosphorylation
Lin et al., Science 1995
:
JNKK also
activated another
MAPK , p38 ( Mpk2 ; the mammalian homolog of HOG1 from yeast ), whose activity is regulated similarly to that of the JNKs
Huwiler et al., Br J Pharmacol 1994
:
2. Both nucleotides stimulate phosphorylation and
activation of
mitogen activated protein kinase and a biphasic phosphorylation of the up-stream
mitogen activated protein kinase kinase
Guan et al., J Biol Chem 1998
:
We also found that overexpression of the constitutively active form of
SEK1 ( SEK1-ED )
increases both p38
MAPK and JNK/SAPK phosphorylation, and increases PGE2 production and Cox-2 expression
Daum et al., FEBS Lett 1998
:
Pervanadate inhibits
mitogen activated protein kinase kinase-1 in a
p38MAPK dependent manner
Ganiatsas et al., Proc Natl Acad Sci U S A 1998
:
SEK1 (
MKK4/JNKK ) is a
mitogen activated protein kinase activator that has been shown to participate in vitro in two stress activated cascades terminating with the SAPK and p38 kinases